Djoussé Luc, Arnett Donna K, Coon Hilary, Province Michael A, Moore Lynn L, Ellison R Curtis
Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Am J Clin Nutr. 2004 Feb;79(2):213-7. doi: 10.1093/ajcn/79.2.213.
An elevated LDL-cholesterol concentration is associated with an increased risk of cardiovascular disease. The association between fruit and vegetable consumption and LDL has been inconsistent.
The objective was to determine whether a high intake of fruit and vegetables is inversely associated with LDL concentrations.
We used data collected from 4466 subjects in the National Heart, Lung, and Blood Institute Family Heart Study to study the association between fruit and vegetable consumption and serum LDL. We used a food-frequency questionnaire to assess fruit and vegetable intakes and regression models to estimate adjusted mean LDL according to fruit and vegetable consumption.
The mean (+/-SD) age of the men (n = 2047) was 51.5 +/- 14.0 y and that of the women (n = 2419) was 52.2 +/- 13.7 y. The average daily serving of fruit and vegetables was 3.2 +/- 1.7 for men and was 3.5 +/- 1.8 for women. Fruit and vegetable consumption was inversely related to LDL: in the categories 0-1.9, 2.0-2.9, 3.0-3.9, and > or = 4 servings/d, multivariate-adjusted mean (95% CI) LDL concentrations were 3.36 (3.28, 3.44), 3.35 (3.27, 3.43), 3.26 (3.17, 3.35), and 3.17 (3.09, 3.25) mmol/L, respectively, for men (P for trend < 0.0001) and 3.35 (3.26, 3.44), 3.22 (3.14, 3.30), 3.21 (3.13, 3.29), and 3.11 (3.04, 3.18), respectively, for women (P for trend < 0.0001). This association was observed across categories of age, education, smoking status, physical activity, and tertiles of Keys score. Exclusion of subjects with prevalent diabetes mellitus or coronary artery disease did not alter these results significantly.
Consumption of fruit and vegetables is inversely related to LDL in men and women.
低密度脂蛋白胆固醇浓度升高与心血管疾病风险增加相关。水果和蔬菜摄入量与低密度脂蛋白之间的关联并不一致。
确定高水果和蔬菜摄入量是否与低密度脂蛋白浓度呈负相关。
我们使用了从美国国立心肺血液研究所家庭心脏研究中的4466名受试者收集的数据，以研究水果和蔬菜摄入量与血清低密度脂蛋白之间的关联。我们使用食物频率问卷来评估水果和蔬菜摄入量，并使用回归模型根据水果和蔬菜摄入量来估计调整后的平均低密度脂蛋白。
男性（n = 2047）的平均（±标准差）年龄为51.5±14.0岁，女性（n = 2419）为52.2±13.7岁。男性每天水果和蔬菜的平均摄入量为3.2±1.7份，女性为3.5±1.8份。水果和蔬菜摄入量与低密度脂蛋白呈负相关：在每天0 - 1.9份、2.0 - 2.9份、3.0 - 3.9份和≥4份的类别中，多变量调整后的男性平均（95%可信区间）低密度脂蛋白浓度分别为3.36（3.28，3.44）、3.35（3.27，3.43）、3.26（3.17，3.35）和3.17（3.09，3.25）mmol/L（趋势P<0.0001），女性分别为3.35（3.26，3.44）、3.22（3.14，3.30）、3.21（3.13，3.29）和3.11（3.04，3.18）（趋势P<0.0001）。在年龄、教育程度、吸烟状况、身体活动和凯斯评分三分位数的各个类别中均观察到这种关联。排除患有糖尿病或冠状动脉疾病的受试者并没有显著改变这些结果。
男性和女性的水果和蔬菜摄入量与低密度脂蛋白呈负相关。
