Scopacasa F, Wishart J M, Horowitz M, Morris H A, Need A G
Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia.
Eur J Clin Nutr. 2004 Feb;58(2):264-9. doi: 10.1038/sj.ejcn.1601777.
To obtain information on the causes of age-related bone loss in men and the concomitant decline in calcium absorption.
Cross-sectional study.
Adelaide, South Australia, Australia.
A total of 95 healthy, Caucasian men (age range 27-87 y).
Calcium absorption declined with age (r=-0.46, P<0.0001), as did 24-h urine calcium, phosphate and creatinine (r>-0.21, P<0.05 for all); serum calcitriol and 25 hydroxyvitamin D did not change with age. Calcium absorption was related to serum calcitriol (r=0.20, P=0.05). An inverse relation between the residual deviations in calcium absorption, after allowing for its dependence on calcitriol, and age (F=5.4, P<0.005) was observed. The 24-h urinary calcium, phosphate and creatinine were all related to calcium absorption (r>0.41, P<0.0001). Forearm bone density fell with age (r=-0.45, P<0.0001) but was not related to calcium absorption, or markers of bone turnover.
In healthy Caucasian males (i) calcium absorption falls, but serum calcitriol does not change with age, (ii) the relation between calcium absorption and serum calcitriol changes with age, indicative of an intestinal resistance to calcitriol and (iii) calcium absorption is a significant determinant of 24-h urinary calcium excretion.
获取有关男性年龄相关性骨质流失的原因以及钙吸收随之下降的信息。
横断面研究。
澳大利亚南澳大利亚州阿德莱德。
总共95名健康的白种男性（年龄范围27 - 87岁）。
钙吸收随年龄下降（r = -0.46，P < 0.0001），24小时尿钙、磷和肌酐也随年龄下降（所有r > -0.21，P < 0.05）；血清骨化三醇和25羟维生素D不随年龄变化。钙吸收与血清骨化三醇相关（r = 0.20，P = 0.05）。在考虑钙吸收对骨化三醇的依赖性后，观察到钙吸收的残余偏差与年龄之间呈负相关（F = 5.4，P < 0.005）。24小时尿钙、磷和肌酐均与钙吸收相关（r > 0.41，P < 0.0001）。前臂骨密度随年龄下降（r = -0.45，P < 0.0001），但与钙吸收或骨转换标志物无关。
在健康的白种男性中，（i）钙吸收下降，但血清骨化三醇不随年龄变化；（ii）钙吸收与血清骨化三醇之间的关系随年龄变化，表明肠道对骨化三醇产生抵抗；（iii）钙吸收是24小时尿钙排泄的重要决定因素。
