Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Clinics (Sao Paulo). 2012 Aug;67(8):911-6. doi: 10.6061/clinics/2012(08)10.
Variations in sex hormones and the calcium balance can influence bone health in men. The present study aimed to examine the relationship between the calcaneal speed of sound and biochemical determinants of bone mass, such as sex hormones, parathyroid hormones and serum calcium.
Data from 549 subjects from the Malaysian Aging Male Study, which included Malay and Chinese men aged 20 years and older residing in the Klang Valley, were used for analysis. The subjects' calcaneal speed of sound was measured, and their blood was collected for biochemical analysis. Two sets of multiple regression models were generated for the total/bioavailable testosterone and estradiol to avoid multicollinearity.
The multiple regression results revealed that bioavailable testosterone and serum total calcium were significant predictors of the calcaneal speed of sound in the adjusted model. After adjustment for ethnicity and body mass index, only bioavailable testosterone remained significant; the total serum calcium was marginally insignificant. In a separate model, the total testosterone and sex hormone-binding globulin were significant predictors, whereas the total serum calcium was marginally insignificant. After adjustment for ethnicity and body mass index (BMI), the significance persisted for total testosterone and SHBG. After further adjustment for age, none of the serum biochemical determinants was a significant predictor of the calcaneal speed of sound.
There is a significant age-dependent relationship between the calcaneal speed of sound and total testosterone, bioavailable testosterone and sex hormone-binding globulin in Chinese and Malay men in Malaysia. The relationship between total serum calcium and calcaneal speed of sound is ethnicity-dependent.
性激素和钙平衡的变化会影响男性的骨骼健康。本研究旨在探讨跟骨超声速度与骨量的生化决定因素（如性激素、甲状旁腺激素和血清钙）之间的关系。
对来自马来西亚男性老龄化研究的 549 名受试者（包括年龄在 20 岁及以上的马来族和华裔男性）的数据进行分析。测量受试者的跟骨超声速度，并采集其血液进行生化分析。为避免多重共线性，针对总/生物可利用睾酮和雌二醇生成了两套多重回归模型。
多元回归结果显示，生物可利用睾酮和血清总钙是调整模型中跟骨超声速度的显著预测因子。在调整了种族和体重指数后，只有生物可利用睾酮仍然具有显著意义；总血清钙则略有不显著。在另一个模型中，总睾酮和性激素结合球蛋白是显著的预测因子，而总血清钙则略有不显著。在进一步调整了年龄后，血清生化指标均不是跟骨超声速度的显著预测因子。
在马来西亚的华裔和马来族男性中，跟骨超声速度与总睾酮、生物可利用睾酮和性激素结合球蛋白之间存在显著的年龄依赖性关系。总血清钙与跟骨超声速度之间的关系与种族有关。
