Department of Epidemiology, Graduate School of Public Health, Seoul National University, Seoul, Korea.
J Endocrinol Invest. 2013 Nov;36(10):791-6. doi: 10.1007/BF03346758.
Serum vitamin D status, as indicated by 25-(OH)D, is inversely associated with glucose homeostasis, lipid profiles, and blood pressure. Evidence on the association of serum vitamin D with metabolic syndrome (MS) however, is very limited in post-menopausal women.
To investigate the association between serum vitamin D and MS.
This study was a crosssectional study including 778 Korean adults who visited a health promotion center in a university hospital from January 2010 to May 2011. MS was defined according to the American Heart Association/National Heart, Lung, and Blood Institute criteria and the Korean Society for the Study of Obesity. MS and its individual components were assessed, as well as serum 25-(OH)D levels with a multiple logistic regression analysis.
The overall prevalence of the MS in participants of this study was 147 (18.9%). After multiple adjustments, compared with the highest quartile serum 25- (OH)D level group (19.9-55.9 ng/ml), the odds ratio for MS in the lowest level group (4.2-9.7 ng/ml) was 2.44 [95% confidence interval (CI)=1.32-4.48], in the lower level group (9.8- 14.1 ng/ml) was 2.20 (95% CI=1.24-3.90), and in the intermediate level group (14.3-19.8 ng/ml) was 1.81 (95% CI=1.02-3.20). Among the components of MS, the adjusted odds ratios for having an elevated blood pressure, and high triglyceride level in the lowest level group were 1.81 (95% CI, 1.15-2.85), 2.74 (95% CI, 1.64-4.57), respectively.
We found that a low serum 25-(OH)D level is significantly associated with the presence of MS and some metabolic components, especially the high triglyceride level and blood pressure in post-menopausal women.
血清维生素 D 状态（以 25-（OH）D 表示）与葡萄糖稳态、脂质谱和血压呈负相关。然而，关于血清维生素 D 与代谢综合征 (MS) 之间的关联的证据在绝经后妇女中非常有限。
研究血清维生素 D 与 MS 之间的关系。
本研究为 2010 年 1 月至 2011 年 5 月期间在一所大学医院的健康促进中心就诊的 778 名韩国成年人进行的横断面研究。MS 根据美国心脏协会/国家心肺血液研究所标准和韩国肥胖研究协会定义。采用多因素逻辑回归分析评估 MS 及其各个成分以及血清 25-（OH）D 水平。
本研究参与者的 MS 总患病率为 147（18.9%）。经多次调整后，与血清 25-（OH）D 水平最高四分位组（19.9-55.9ng/ml）相比，血清 25-（OH）D 水平最低四分位组（4.2-9.7ng/ml）的 MS 比值比为 2.44[95%可信区间（CI）=1.32-4.48]，在较低水平组（9.8-14.1ng/ml）为 2.20（95%CI=1.24-3.90），在中间水平组（14.3-19.8ng/ml）为 1.81（95%CI=1.02-3.20）。在 MS 的各个成分中，在最低水平组中血压升高和高甘油三酯水平的调整比值比分别为 1.81（95%CI，1.15-2.85）和 2.74（95%CI，1.64-4.57）。
我们发现血清 25-（OH）D 水平较低与 MS 的存在及其某些代谢成分（尤其是绝经后妇女的高甘油三酯水平和血压）显著相关。
