Falcón M, Oliva J, Osuna E, Barba A, Luna A
Department of Forensic Medicine, University of Murcia, Espinardo, E-30100 Murcia, Spain.
Toxicology. 2004 Feb 15;195(2-3):203-8. doi: 10.1016/j.tox.2003.10.009.
Organochlorinated insecticides are ubiquitous toxicants that are transplacentally transferred from mother to fetus and are reported to produce adverse health effects in pregnant woman and neonates. To investigate hexachlorocyclohexane (HCH) and 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) exposure in pregnant woman, a total of 102 placentas were analyzed by a gas chromatograph equipped with electron capture detector. Organochlorine residues were found in 69.6% of the samples. Lindane was detected in 24.5%, alpha-HCH in 2.9%, beta-HCH in 6.9%, p,p'-DDE in 44.1%, p,p'-DDT in 14.7% and p,p'-DDD in 10.8% of the samples. The pattern of dispersal by these substances in Murcia is similar to that described by different authors in other countries. Therefore, the past use of DDT and the present employment of lindane seem to be reflected in body tissues of the residents of this area.
有机氯杀虫剂是普遍存在的有毒物质，可通过胎盘从母亲转移至胎儿，据报道会对孕妇和新生儿产生不良健康影响。为调查孕妇体内六氯环己烷（HCH）和1,1,1-三氯-2,2-双（4-氯苯基）乙烷（DDT）的暴露情况，使用配备电子捕获检测器的气相色谱仪对总共102份胎盘进行了分析。在69.6%的样本中发现了有机氯残留。在24.5%的样本中检测到林丹，2.9%的样本中检测到α-HCH，6.9%的样本中检测到β-HCH，44.1%的样本中检测到p,p'-DDE，14.7%的样本中检测到p,p'-DDT，10.8%的样本中检测到p,p'-DDD。这些物质在穆尔西亚的分布模式与其他国家不同作者所描述的相似。因此，过去使用DDT以及目前使用林丹的情况似乎在该地区居民的身体组织中有所体现。
