De Renzo Amalia, Persico Eliana, de Marino Fedele, di Giacomo Russo Giovanni, Notaro Rosario, di Grazia Carmen, Picardi Marco, Santoro Lidia, Torella Roberto, Rotoli Bruno, Persico Marcello
Hematology Division, Federico II University, Naples, Italy.
Haematologica. 2002 Jul;87(7):714-8; discussion 718.
During the last decade an epidemiological association between hepatitis C virus (HCV) and B-cell lymphoproliferative disorders (B-LPD) has been reported; the same association has not been observed for Hodgkin's disease (HD). Hepatitis G virus (HGV) shares genetic and biological features with HCV, thus it might also be involved in lymphomagenesis.
The aim of this study was to compare the prevalence of HCV and HGV infection in patients at diagnosis of B-LPD or HD.
We tested 227 consecutive untransfused patients (127 with B-LPD and 100 with HD) and 110 healthy controls. The prevalence of HCV infection was significantly higher in B-LPD patients than in controls (17.3% vs. 1.8%, p<0.002 ), whereas it was the same in HD patients as in controls. In contrast, the prevalence of HGV was significantly higher in patients, both those with B-LPD (7.8% vs. 0.9%, p<0.03) and those with HD (13% vs. 0.9%, p<0.002), than in controls. Among the various B-LPD tested, HGV infection was more frequent in B-NHL (11.5%).
Our data support the hypothesis that HGV infection may play a role in lymphomagenesis and that this role is different and separate from that of HCV.
在过去十年间，已有报告称丙型肝炎病毒（HCV）与B细胞淋巴增殖性疾病（B-LPD）之间存在流行病学关联；但未观察到霍奇金病（HD）与HCV有同样的关联。庚型肝炎病毒（HGV）与HCV具有共同的遗传和生物学特征，因此它也可能参与淋巴瘤的发生。
本研究旨在比较B-LPD或HD患者诊断时HCV和HGV感染的患病率。
我们检测了227例连续的未输血患者（127例B-LPD患者和100例HD患者）以及110名健康对照者。B-LPD患者中HCV感染的患病率显著高于对照组（17.3%对1.8%，p<0.002），而HD患者中的患病率与对照组相同。相比之下，B-LPD患者（7.8%对0.9%，p<0.03）和HD患者（13%对0.9%，p<0.002）中HGV的患病率均显著高于对照组。在检测的各种B-LPD中，B-NHL中HGV感染更为常见（11.5%）。
我们的数据支持以下假设，即HGV感染可能在淋巴瘤发生中起作用，且该作用与HCV不同且相互独立。
