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霍乱的人类、社会及科学遗产。

The human, societal, and scientific legacy of cholera.

作者信息

Greenough William B

机构信息

Division of Geriatric Medicine, Department of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

出版信息

J Clin Invest. 2004 Feb;113(3):334-9. doi: 10.1172/JCI20982.

DOI:10.1172/JCI20982
PMID:14755327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC324550/
Abstract

The recent history of research on cholera illustrates the importance of establishing research and care facilities equipped with advanced technologies at locations where specific health problems exist. It is in such settings, where scientific research is often considered difficult due to poverty and the lack of essential infrastructure, that investigators from many countries are able to make important advances. On this, the 25th anniversary of the founding of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), this article seeks to recount the Centre's demonstration of how high-quality research on important global health issues, including cholera, can be accomplished in conditions that may be considered by many as unsuitable for scientific research.

摘要

霍乱的近期研究历史表明,在存在特定健康问题的地区建立配备先进技术的研究和护理设施非常重要。正是在这样的环境中,由于贫困和缺乏基本基础设施,科学研究往往被认为困难重重,但来自许多国家的研究人员却能够取得重要进展。值此孟加拉国腹泻病研究国际中心(ICDDR,B)成立25周年之际,本文旨在讲述该中心如何证明,在许多人可能认为不适合科学研究的条件下,仍可完成对包括霍乱在内的重要全球健康问题的高质量研究。

相似文献

1
The human, societal, and scientific legacy of cholera.霍乱的人类、社会及科学遗产。
J Clin Invest. 2004 Feb;113(3):334-9. doi: 10.1172/JCI20982.
2
ICDDR,B and ORS: the history of a miracle discovery.国际腹泻病研究中心(ICDDR,B)与口服补液盐(ORS):一项奇迹发现的历程
Glimpse. 1994 Mar-Jun;16(2-3):3-4.
3
The controversial and short-lived early use of rehydration therapy for cholera.霍乱早期补液疗法存在争议且为时短暂的应用。
Clin Infect Dis. 2008 Nov 15;47(10):1315-9. doi: 10.1086/592580.
4
Hillary Clinton impressed by the Centre's work.希拉里·克林顿对该中心的工作印象深刻。
Glimpse. 1995 Mar-Apr;17(2):1,4,7.
5
Acceptance speech.获奖感言。
Glimpse. 1994 Mar-Jun;16(2-3):11-2.
6
Address.地址。
Glimpse. 1994 Mar-Jun;16(2-3):13-4.
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A new era in the history of cholera: the road to elimination.霍乱历史上的一个新时代:通往消除霍乱之路。
Int J Epidemiol. 2013 Dec;42(6):1537-40. doi: 10.1093/ije/dyt229.
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Introductory address by Dr Demissie Habte on the occasion of the 25th anniversary of ORS.德米西·哈贝特博士在口服补液盐问世25周年之际发表的开幕致辞。
Glimpse. 1994 Mar-Jun;16(2-3):7-8.
9
Oral fluid therapy of cholera among Bangladesh refugees. 1973.1973年孟加拉国难民霍乱的口服补液疗法。
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A thousand tears...a thousand smiles: a celebration worth remembering.千滴泪水……千缕笑容:一场值得铭记的庆典。
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2
The forgotten pandemic: how understanding cholera illuminated mechanisms of chloride channels in multiple diseases.被遗忘的大流行:霍乱研究如何揭示多种疾病中氯离子通道的机制
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Cholera amid COVID-19: Call from three nations; India, Bangladesh, and Nepal.新冠疫情下的霍乱:来自印度、孟加拉国和尼泊尔三国的呼吁。
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Cholera.霍乱。
Lancet. 2012 Jun 30;379(9835):2466-2476. doi: 10.1016/S0140-6736(12)60436-X.
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Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages.霍乱的季节性流行与环境霍乱噬菌体的流行率呈负相关。
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1702-7. doi: 10.1073/pnas.0408992102. Epub 2005 Jan 14.

本文引用的文献

1
Water and electrolyte studies in cholera.霍乱的水与电解质研究
J Clin Invest. 1959 Nov;38(11):1879-89. doi: 10.1172/JCI103965.
2
Enterotoxicity of bacteria-free culture-filtrate of Vibrio cholerae.霍乱弧菌无细胞培养滤液的肠毒性
Nature. 1959 May 30;183(4674):1533-4. doi: 10.1038/1831533a0.
3
Assessing the impact of the green revolution, 1960 to 2000.评估1960年至2000年绿色革命的影响。
Science. 2003 May 2;300(5620):758-62. doi: 10.1126/science.1078710.
4
Intestinal ion transport and the pathophysiology of diarrhea.肠道离子转运与腹泻的病理生理学
J Clin Invest. 2003 Apr;111(7):931-43. doi: 10.1172/JCI18326.
5
Palatability, reactogenicity and immunogenicity of engineered live oral cholera vaccine CVD 103-HgR in Chilean infants and toddlers.工程化活口服霍乱疫苗CVD 103-HgR在智利婴幼儿中的适口性、反应原性和免疫原性。
Pediatr Infect Dis J. 1999 Jul;18(7):624-30. doi: 10.1097/00006454-199907000-00011.
6
Global climate and infectious disease: the cholera paradigm.全球气候与传染病:霍乱范例
Science. 1996 Dec 20;274(5295):2025-31. doi: 10.1126/science.274.5295.2025.
7
Lysogenic conversion by a filamentous phage encoding cholera toxin.由编码霍乱毒素的丝状噬菌体进行的溶原性转变。
Science. 1996 Jun 28;272(5270):1910-4. doi: 10.1126/science.272.5270.1910.
8
Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototype.新型霍乱大流行的出现:霍乱弧菌O139毒力决定因素的分子分析及减毒活疫苗原型的研制
J Infect Dis. 1994 Aug;170(2):278-83. doi: 10.1093/infdis/170.2.278.
9
Magic bullet: the history of oral rehydration therapy.神奇疗法:口服补液疗法的历史
Med Hist. 1994 Oct;38(4):363-97. doi: 10.1017/s0025727300036905.
10
Rice oral rehydration solution hastens recovery from dysentery.
J Diarrhoeal Dis Res. 1995 Mar;13(1):8-11.