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本文引用的文献

1
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health.自身反应性T细胞反应在糖尿病中表现出促炎极化，但在健康状态下表现出调节性表型。
J Clin Invest. 2004 Feb;113(3):451-63. doi: 10.1172/JCI19585.
2
Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms.移植耐受中的调节性T细胞和树突状细胞：分子标志物与机制
Immunol Rev. 2003 Dec;196:109-24. doi: 10.1046/j.1600-065x.2003.00078.x.
3
Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies.早期婴儿喂养与1型糖尿病相关自身抗体的发生风险
JAMA. 2003 Oct 1;290(13):1721-8. doi: 10.1001/jama.290.13.1721.
4
Timing of initial cereal exposure in infancy and risk of islet autoimmunity.婴儿期初次接触谷物的时间与胰岛自身免疫风险
JAMA. 2003 Oct 1;290(13):1713-20. doi: 10.1001/jama.290.13.1713.
5
Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).通过 FcR 非结合性抗 CD3 单克隆抗体 hOKT3γ1(Ala-Ala)激活人 T 细胞。
J Clin Invest. 2003 Feb;111(3):409-18. doi: 10.1172/JCI16090.
6
Epstein-Barr virus encoded interleukin-10 inhibits HLA-class I, ICAM-1, and B7 expression on human monocytes: implications for immune evasion by EBV.爱泼斯坦-巴尔病毒编码的白细胞介素-10抑制人单核细胞上的HLA-I类分子、细胞间黏附分子-1和B7分子的表达：对爱泼斯坦-巴尔病毒免疫逃逸的影响
Virology. 2002 Dec 20;304(2):342-51. doi: 10.1006/viro.2002.1716.
7
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.免疫抑制药物可诱导体外产生白细胞介素10的调节性CD4(+) T细胞，而1型辅助性T细胞（Th1）和2型辅助性T细胞（Th2）诱导细胞因子则会抑制其产生。
J Exp Med. 2002 Mar 4;195(5):603-16. doi: 10.1084/jem.20011629.
8
Suppressor T cells--they're back and critical for regulation of autoimmunity!抑制性T细胞——它们再度出现，对自身免疫的调节至关重要！
Immunol Rev. 2001 Aug;182:149-63. doi: 10.1034/j.1600-065x.2001.1820112.x.
9
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study.维生素D摄入量与1型糖尿病风险：一项出生队列研究。
Lancet. 2001 Nov 3;358(9292):1500-3. doi: 10.1016/S0140-6736(01)06580-1.
10
IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.干扰素-α和白细胞介素-10诱导人1型调节性T细胞分化。
J Immunol. 2001 May 1;166(9):5530-9. doi: 10.4049/jimmunol.166.9.5530.

实现抗原特异性免疫调节。

Achieving antigen-specific immune regulation.

作者信息

Herold Kevan C

机构信息

Naomi Berrie Diabetes Center, Division of Endocrinology and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

出版信息

J Clin Invest. 2004 Feb;113(3):346-9. doi: 10.1172/JCI20963.

DOI:10.1172/JCI20963
PMID:14755329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC324549/
Abstract

A study in this issue of the JCI shows that in response to autoantigens consisting of peptides from normal proteins, patients with diabetes mount a T cell response characterized by production of IFN-gamma (see the related article beginning on page 451). However, in response to these same antigens, T cells from normal control subjects produce IL-10. The antigen-specific response characterized by release of a regulatory cytokine suggests a mechanism for the control of autoimmunity that is initiated at the time of antigen presentation.

摘要

本期《临床研究杂志》中的一项研究表明，针对由正常蛋白质肽段组成的自身抗原，糖尿病患者会产生以干扰素-γ分泌为特征的T细胞应答（见第451页开始的相关文章）。然而，针对相同抗原，正常对照受试者的T细胞产生白细胞介素-10。以调节性细胞因子释放为特征的抗原特异性应答提示了一种在抗原呈递时启动的自身免疫控制机制。