实现抗原特异性免疫调节。
Achieving antigen-specific immune regulation.
作者信息
Herold Kevan C
机构信息
Naomi Berrie Diabetes Center, Division of Endocrinology and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
出版信息
J Clin Invest. 2004 Feb;113(3):346-9. doi: 10.1172/JCI20963.
Abstract
A study in this issue of the JCI shows that in response to autoantigens consisting of peptides from normal proteins, patients with diabetes mount a T cell response characterized by production of IFN-gamma (see the related article beginning on page 451). However, in response to these same antigens, T cells from normal control subjects produce IL-10. The antigen-specific response characterized by release of a regulatory cytokine suggests a mechanism for the control of autoimmunity that is initiated at the time of antigen presentation.
摘要
本期《临床研究杂志》中的一项研究表明，针对由正常蛋白质肽段组成的自身抗原，糖尿病患者会产生以干扰素-γ分泌为特征的T细胞应答（见第451页开始的相关文章）。然而，针对相同抗原，正常对照受试者的T细胞产生白细胞介素-10。以调节性细胞因子释放为特征的抗原特异性应答提示了一种在抗原呈递时启动的自身免疫控制机制。
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本文引用的文献
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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health.自身反应性T细胞反应在糖尿病中表现出促炎极化，但在健康状态下表现出调节性表型。
J Clin Invest. 2004 Feb;113(3):451-63. doi: 10.1172/JCI19585.
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Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms.移植耐受中的调节性T细胞和树突状细胞：分子标志物与机制
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Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies.早期婴儿喂养与1型糖尿病相关自身抗体的发生风险
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