大麻素与神经炎症
Cannabinoids and neuroinflammation.
作者信息
Walter Lisa, Stella Nephi
机构信息
Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
出版信息
Br J Pharmacol. 2004 Mar;141(5):775-85. doi: 10.1038/sj.bjp.0705667. Epub 2004 Feb 2.
Abstract
Growing evidence suggests that a major physiological function of the cannabinoid signaling system is to modulate neuroinflammation. This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal models of clinical neuroinflammatory conditions, specifically rodent models of multiple sclerosis, and second by describing the endogenous cannabinoid (endocannabinoid) system components in immune cells. Our aim is to identify immune functions modulated by cannabinoids that could account for their anti-inflammatory effects in these animal models.
摘要
越来越多的证据表明，大麻素信号系统的一个主要生理功能是调节神经炎症。本综述在分子、细胞和整体动物水平上讨论了大麻素化合物的抗炎特性，首先通过研究使用临床神经炎症病症的体内动物模型（特别是多发性硬化症的啮齿动物模型）获得的大麻素抗炎作用的证据，其次通过描述免疫细胞中的内源性大麻素（内源性大麻素）系统成分。我们的目的是确定大麻素调节的免疫功能，这些功能可以解释它们在这些动物模型中的抗炎作用。
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