Komatsu H, Suga C, Miyakawa K, Miyakawa J, Sugiyama A, Ikezawa Z, Nakajima H
Department of Dermatology, Yokohama City University, School of Medicine.
Arerugi. 1990 Apr;39(4):402-9.
The results were as follows; 9 cases (36%) showed improvement, 10 cases (40%) mild improvement and 6 cases (24%) no improvement. Rice-RAST titers (PRU/ml) decreased in accordance with the clinical effects, namely most remarkably in the 1st group. Wheat-RAST titers also decreased noticeably in the 1st group even though they were eating wheat everyday, but increased in the 3rd group. In these cases the rice antigen may act on the production of IgE antibodies specific not only to rice but also to wheat as an initiator antigen. The serum IgE values increased in the 3rd group, but not in the other groups. In all groups, eosinophilia was seen, but no significant changes in condition after rice elimination diet were observed. Based on these results, the probable role of rice allergy in the pathogenesis of severe AD in Japan was discussed.
9例（36%）有改善，10例（40%）有轻度改善，6例（24%）无改善。大米RAST效价（PRU/ml）随临床疗效而降低，即在第一组中最为显著。小麦RAST效价在第一组中也显著降低，尽管他们每天都食用小麦，但在第三组中却升高了。在这些病例中，大米抗原可能作为起始抗原，不仅作用于对大米特异性的IgE抗体的产生，还作用于对小麦特异性的IgE抗体的产生。第三组血清IgE值升高，其他组则未升高。所有组均出现嗜酸性粒细胞增多，但在排除大米饮食后病情未见明显变化。基于这些结果，讨论了大米过敏在日本重度特应性皮炎发病机制中的可能作用。
