Papamichael Christos, Karatzis Emmanouil, Karatzi Kalliopi, Aznaouridis Konstantinos, Papaioannou Theodoros, Protogerou Athanassios, Stamatelopoulos Kimon, Zampelas Antonis, Lekakis John, Mavrikakis Myron
Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece.
Am Heart J. 2004 Feb;147(2):E5. doi: 10.1016/S0002.
Long-term smoking is believed to cause endothelial dysfunction via increased oxidative stress, whereas short-term smoking impairs vasodilatation through an as yet undefined mechanism. However, red wine and its constituents have a powerful antioxidant effect both in long-term and acute consumption. The aim of the current study was to investigate whether red wine, with or without alcohol, influences endothelial dysfunction induced by acute cigarette smoking.
Sixteen healthy volunteers (8 males and 8 females) were recruited for a double-blind, crossover study, comprising 3 study days. Each subject smoked 1 cigarette, or smoked and drank 250 mL of red wine, or smoked and drank 250 mL of dealcoholized red wine. Flow-mediated dilatation (FMD) was measured after fasting and 15, 30, 60, and 90 minutes after each trial (smoke or smoke and drink either beverage).
Acute smoking of 1 cigarette caused a reduction in FMD (P <.001), which was statistically significant 15, 30, and 60 minutes after the inhalation of smoke compared to baseline levels (P <.001, P <.001, P =.043, respectively). However, simultaneous ingestion of either red wine or dealcoholized red wine with smoking did not lead to a change in FMD.
Acute smoking caused a significant impairment in endothelial function. Simultaneous consumption of red wine or dealcoholized red wine with smoking decreased smoke's harmful effect on endothelium.
长期吸烟被认为会通过增加氧化应激导致内皮功能障碍，而短期吸烟则通过一种尚未明确的机制损害血管舒张功能。然而，红酒及其成分在长期和短期饮用时都具有强大的抗氧化作用。本研究的目的是探讨红酒（含酒精或不含酒精）是否会影响急性吸烟引起的内皮功能障碍。
招募了16名健康志愿者（8名男性和8名女性）进行一项双盲交叉研究，包括3个研究日。每位受试者吸1支烟，或吸烟并饮用250毫升红酒，或吸烟并饮用250毫升脱醇红酒。在每次试验（吸烟或吸烟并饮用任一饮料）后禁食以及15、30、60和90分钟时测量血流介导的舒张功能（FMD）。
吸1支烟会导致FMD降低（P<.001），与基线水平相比，吸烟后15、30和60分钟时具有统计学意义（分别为P<.001、P<.001、P=.043）。然而，吸烟时同时摄入红酒或脱醇红酒并不会导致FMD发生变化。
急性吸烟会显著损害内皮功能。吸烟时同时饮用红酒或脱醇红酒可降低吸烟对内皮的有害影响。
