Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
PLoS One. 2013 Jul 24;8(7):e69818. doi: 10.1371/journal.pone.0069818. Print 2013.
The acute effects of grape polyphenols on endothelial function in adults are inconsistent. Here, we performed meta-analyses to determine these acute effects as measured by flow-mediated dilation (FMD).
Trials were searched in PubMed, Embase and the Cochrane Library database. Summary estimates of weighted mean differences (WMDs) and 95% CIs were obtained by using random-effects models. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. The protocol details of our meta-analysis have been submitted to the PROSPERO register and our registration number is CRD42013004157.
Nine studies were included in the present meta-analyses. The results showed that the FMD level was significantly increased in the initial 120 min after intake of grape polyphenols as compared with controls. Meta-regression and subgroup analyses were performed and showed that a health status was the main effect modifier of the significant heterogeneity. Subgroups indicated that intake of grape polyphenols could significantly increase FMD in healthy subjects, and the increased FMD appeared to be more obviously in subjects with high cardiovascular risk factors. Moreover, the peak effect of grape polyphenols on FMD in healthy subjects was found 30 min after ingestion, which was different from the effect in subjects with high cardiovascular risk factors, in whom the peak effect was found 60 min after ingestion.
Endothelial function can be significantly improved in healthy adults in the initial 2 h after intake of grape polyphenols. The acute effect of grape polyphenols on endothelial function may be more significant but the peak effect is delayed in subjects with a smoking history or coronary heart disease as compared with the healthy subjects.
关于葡萄多酚对成年人内皮功能的急性影响，结果并不一致。在此，我们进行了荟萃分析，以确定这些急性影响，其通过血流介导的扩张（FMD）来衡量。
我们在 PubMed、Embase 和 Cochrane Library 数据库中搜索试验。使用随机效应模型获得加权均数差值（WMD）和 95%置信区间（CI）的汇总估计值。进行荟萃回归和亚组分析以确定异质性的来源。我们的荟萃分析方案已提交给 PROSPERO 注册处，注册号为 CRD42013004157。
共有 9 项研究纳入本荟萃分析。结果表明，与对照组相比，葡萄多酚摄入后 120 分钟内，FMD 水平显著升高。进行荟萃回归和亚组分析，结果表明健康状况是显著异质性的主要效应修饰剂。亚组表明，葡萄多酚的摄入可以显著增加健康受试者的 FMD，并且在心血管高风险因素的受试者中，增加的 FMD 似乎更为明显。此外，在健康受试者中，葡萄多酚对 FMD 的峰值效应出现在摄入后 30 分钟，而在心血管高风险因素的受试者中，峰值效应出现在摄入后 60 分钟。
在摄入葡萄多酚后的最初 2 小时内，健康成年人的内皮功能可以显著改善。与健康受试者相比，有吸烟史或冠心病的受试者内皮功能对葡萄多酚的急性效应可能更为显著，但峰值效应延迟。
