Leszczynski Dariusz, Nylund Reetta, Joenväärä Sakari, Reivinen Jukka
Bio-NIR Research Group at the Radiobiology Laboratory, STUK - Radiation and Nuclear Safety Authority, Helsinki, Finland.
Proteomics. 2004 Feb;4(2):426-31. doi: 10.1002/pmic.200300646.
We argue that the use of high-throughput screening techniques, although expensive and laborious, is justified and necessary in studies that examine biological effects of mobile phone radiation. The "case of hsp27 protein" presented here suggests that even proteins with only modestly altered (by exposure to mobile phone radiation) expression and activity might have an impact on cell physiology. However, this short communication does not attempt to present the full scientific evidence that is far too large to be presented in a single article and that is being prepared for publication in three separate research articles. Examples of the experimental evidence presented here were designed to show the flow of experimental process demonstrating that the use of high-throughput screening techniques might help in rapid identification of the responding proteins. This, in turn, can help in speeding up of the process of determining whether these changes might affect human health.*
我们认为，尽管高通量筛选技术成本高昂且耗时费力，但在研究手机辐射的生物学效应时，其使用是合理且必要的。此处呈现的“hsp27蛋白案例”表明，即使是那些（因暴露于手机辐射而）表达和活性仅有适度改变的蛋白质，也可能对细胞生理产生影响。然而，这篇简短的通讯并未试图呈现完整的科学证据，这些证据数量庞大，无法在一篇文章中全部呈现，目前正准备以三篇独立的研究文章发表。此处展示的实验证据示例旨在呈现实验过程流程，以证明使用高通量筛选技术可能有助于快速识别做出反应的蛋白质。反过来，这有助于加快确定这些变化是否可能影响人类健康的进程。
