Nowrousian Minou, Würtz Christian, Pöggeler Stefanie, Kück Ulrich
Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, 44780, Bochum, Germany.
Fungal Genet Biol. 2004 Mar;41(3):285-92. doi: 10.1016/j.fgb.2003.10.005.
One of the most challenging parts of large scale sequencing projects is the identification of functional elements encoded in a genome. Recently, studies of genomes of up to six different Saccharomyces species have demonstrated that a comparative analysis of genome sequences from closely related species is a powerful approach to identify open reading frames and other functional regions within genomes [Science 301 (2003) 71, Nature 423 (2003) 241]. Here, we present a comparison of selected sequences from Sordaria macrospora to their corresponding Neurospora crassa orthologous regions. Our analysis indicates that due to the high degree of sequence similarity and conservation of overall genomic organization, S. macrospora sequence information can be used to simplify the annotation of the N. crassa genome.
大规模测序项目中最具挑战性的部分之一是识别基因组中编码的功能元件。最近，对多达六种不同酿酒酵母物种基因组的研究表明，对亲缘关系相近物种的基因组序列进行比较分析是识别基因组内开放阅读框和其他功能区域的有力方法[《科学》301（2003年）71，《自然》423（2003年）241]。在此，我们展示了大孢粪壳菌选定序列与其对应的粗糙脉孢菌直系同源区域的比较。我们的分析表明，由于序列相似性高以及整体基因组组织的保守性，大孢粪壳菌的序列信息可用于简化粗糙脉孢菌基因组的注释。
Zotero 插件