Urban Robert M, Turner Thomas M, Hall Deborah J, Infanger Susan I, Cheema Naveed, Lim Tae-Hong, Moseley Jon, Carroll Michael, Roark Michael
Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Ill, USA.
Orthopedics. 2004 Jan;27(1 Suppl):s113-8. doi: 10.3928/0147-7447-20040102-06.
A new, modified calcium sulfate has been developed with a different crystalline structure and a compressive strength similar to many calcium phosphate materials, but with a resorption profile only slightly slower than conventional surgical-grade calcium sulfate. A canine bilateral defect model was used to compare restoration of defects treated with the modified calcium sulfate compared to treatment using conventional calcium sulfate pellets after 6, 13, and 26 weeks. The modified calcium sulfate pellets were as effective as conventional calcium sulfate pellets with regard to the area fraction and compressive strength of newly formed bone in the treated bone defects. Mechanical testing demonstrated that the initial compressive strength of the modified material was increased nearly three-fold compared to that of conventional surgical-grade calcium sulfate. This increase potentially allows for its use in a broader range of clinical applications, such as vertebral and subchondral defects.
一种新型的改性硫酸钙已被研发出来，其具有不同的晶体结构，抗压强度与许多磷酸钙材料相似，但吸收过程仅比传统外科级硫酸钙略慢。使用犬双侧缺损模型，比较在6周、13周和26周后，用改性硫酸钙治疗的缺损与使用传统硫酸钙颗粒治疗的缺损的修复情况。在治疗的骨缺损中，就新形成骨的面积分数和抗压强度而言，改性硫酸钙颗粒与传统硫酸钙颗粒一样有效。力学测试表明，与传统外科级硫酸钙相比，改性材料的初始抗压强度提高了近三倍。这种提高有可能使其应用于更广泛的临床领域，如椎体和软骨下缺损。
