Urban Robert M, Turner Thomas M, Hall Deborah J, Inoue Nozomu, Gitelis Steven
Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
Clin Orthop Relat Res. 2007 Jun;459:110-7. doi: 10.1097/BLO.0b013e318059b902.
Calcium phosphates (CaPO4) and faster-resorbing calcium sulfate (CaSO4) are successfully employed as synthetic bone grafts for treatment of contained defects. We used a canine critical-sized bone defect model to study an injectable CaSO4/CaPO4 composite graft that incorporated a matrix of CaSO4 and dicalcium phosphate dihydrate into which beta-tricalcium phosphate granules were distributed. The area fraction, ultimate compressive stress, and elastic modulus of restored bone and the relative rates of material resorption were compared between the CaSO4/CaPO4 composite graft and pure CaSO4 pellets and to normal canine bone. The area fraction of bone in stained sections and the ultimate compressive stress of the regenerated bone were greater using the CaSO4/CaPO4 composite graft compared to pure CaSO4 pellets after 13 and 26 weeks and were greater than normal bone. The elastic modulus of restored bone in defects treated with CaSO4/CaPO4 composite graft was greater than in defects treated with CaSO4 pellets after 26 weeks, but similar to specimens of normal bone. A small amount of CaSO4/CaPO4 composite graft and no CaSO4 pellets remained after 13 or 26 weeks. This novel CaSO4/CaPO4 composite holds promise for clinical applications where a strong, injectable, slower-resorbing, and biocompatible bone graft substitute would be advantageous.
磷酸钙（CaPO4）和吸收更快的硫酸钙（CaSO4）已成功用作合成骨移植材料，用于治疗局限性骨缺损。我们使用犬类临界尺寸骨缺损模型，研究了一种可注射的CaSO4/CaPO4复合移植物，该移植物将硫酸钙和二水磷酸二钙基质与β-磷酸三钙颗粒混合在一起。比较了CaSO4/CaPO4复合移植物、纯CaSO4颗粒与正常犬骨的修复骨面积分数、极限抗压应力、弹性模量以及材料吸收的相对速率。13周和26周后，与纯CaSO4颗粒相比，使用CaSO4/CaPO4复合移植物的染色切片中骨的面积分数和再生骨的极限抗压应力更大，且大于正常骨。26周后，用CaSO4/CaPO4复合移植物治疗的缺损中修复骨的弹性模量大于用CaSO4颗粒治疗的缺损，但与正常骨标本相似。13周或26周后，仅残留少量CaSO4/CaPO4复合移植物，而没有CaSO4颗粒残留。这种新型的CaSO4/CaPO4复合材料在需要强韧、可注射、吸收较慢且生物相容性良好的骨移植替代物的临床应用中具有前景。
