Blum Barbara, Moseley Jon, Miller Leasa, Richelsoph Kelly, Haggard Warren
Wright Medical Technology, Inc., Arlington, Tenn, USA.
Orthopedics. 2004 Jan;27(1 Suppl):s161-5. doi: 10.3928/0147-7447-20040102-17.
Osteoinductivity of demineralized bone matrix has been attributed to bone morphogenetic proteins (BMP). Other growth factors, including insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta1 (TGF-beta1), have also been detected in demineralized bone matrix. Success of bone graft substitutes containing demineralized bone matrix has been assumed to be closely associated with osteoinductivity of the demineralized bone matrix. Because of differences in bone characteristics between donors and tissue banks, confirmation and measurement of osteoinductivity may play a crucial role in predicting the success of the bone graft substitute. In the current studies, BMP-2, BMP-4, TGF-beta1, and IGF-1 were measured in demineralized bone matrix. A strong association was noted between BMP-2 and TGF-beta1 levels. A strong association was also found between BMP-2 and new bone formation in an ectopic nude rat model.
脱矿骨基质的骨诱导性被认为归因于骨形态发生蛋白（BMP）。在脱矿骨基质中还检测到了其他生长因子，包括胰岛素样生长因子-1（IGF-1）和转化生长因子-β1（TGF-β1）。含有脱矿骨基质的骨移植替代物的成功被认为与脱矿骨基质的骨诱导性密切相关。由于供体和组织库之间骨特性的差异，骨诱导性的确认和测量可能在预测骨移植替代物的成功方面起着关键作用。在当前的研究中，对脱矿骨基质中的BMP-2、BMP-4、TGF-β1和IGF-1进行了测量。发现BMP-2和TGF-β1水平之间存在强关联。在异位裸鼠模型中还发现BMP-2与新骨形成之间存在强关联。
