可提取的骨形态发生蛋白及其与无胸腺小鼠模型体内试验中诱导新骨形成的相关性。
Extractable bone morphogenetic protein and correlation with induced new bone formation in an in vivo assay in the athymic mouse model.
作者信息
Honsawek Sittisak, Powers Ralph M, Wolfinbarger Lloyd
机构信息
LifeNet, 5809 Ward Court, Virginia Beach, VA 23455, USA.
出版信息
Cell Tissue Bank. 2005;6(1):13-23. doi: 10.1007/s10561-005-1445-4.
A correlation between extractable bone morphogenetic proteins (BMPs) in demineralized bone matrix (DBM) and osteoinduction has been suggested. Extractable BMP-4 and osteoinductivity of DBM from 40 donors were assessed using enzyme-linked immunosorbent assay (ELISA) and in vivo athymic mouse assay, respectively. Extractable BMP-4 level averaged 3.7 +/- 0.21 ng/g of DBM and correlated with osteoinductivity of the DBM in an in vivo assessment of induced newbone formation.
已有人提出脱矿骨基质（DBM）中可提取的骨形态发生蛋白（BMPs）与骨诱导之间存在相关性。分别使用酶联免疫吸附测定（ELISA）和体内无胸腺小鼠试验，对来自40名供体的DBM中可提取的BMP-4和骨诱导活性进行了评估。可提取的BMP-4水平平均为3.7±0.21 ng/g DBM，并且在诱导新骨形成的体内评估中与DBM的骨诱导活性相关。
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