Maskey Rajendra P, Helmke Elisabeth, Laatsch Hartmut
Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, Göttingen D-37077, Germany.
J Antibiot (Tokyo). 2003 Nov;56(11):942-9. doi: 10.7164/antibiotics.56.942.
In our screening of marine Streptomycetes for bioactive compounds, in addition to the known metabolites rabelomycin (1), fridamycin D (2b), N-benzylacetamide and N-(2'-phenylethyl)acetamide, two new anthracycline antibiotics designated as himalomycin A (2c) and B (2d) were isolated from the culture broth of the marine Streptomyces sp. isolate B6921. The structure of the new antibiotics was determined by comparison of the NMR data with those of fridamycin D (2b) and by detailed interpretation of mass, 1D and 2D NMR spectra.
在我们对海洋链霉菌进行生物活性化合物筛选的过程中，除了已知的代谢产物拉贝洛霉素（1）、弗里达霉素D（2b）、N-苄基乙酰胺和N-（2'-苯乙基）乙酰胺外，还从海洋链霉菌菌株B6921的培养液中分离出两种新的蒽环类抗生素，分别命名为喜玛拉霉素A（2c）和B（2d）。通过将核磁共振数据与弗里达霉素D（2b）的数据进行比较，并对质谱、一维和二维核磁共振谱进行详细解析，确定了这两种新抗生素的结构。
