钱德拉纳霉素A至C：通过改变培养基成分和生长条件，从海洋马杜拉放线菌属菌株M048生产新型抗癌抗生素。
Chandrananimycins A approximately C: production of novel anticancer antibiotics from a marine Actinomadura sp. isolate M048 by variation of medium composition and growth conditions.
作者信息
Maskey Rajendra P, Li Fuchao, Qin Song, Fiebig Heinz H, Laatsch Hartmut
机构信息
Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
出版信息
J Antibiot (Tokyo). 2003 Jul;56(7):622-9. doi: 10.7164/antibiotics.56.622.
PMID:14513905
Abstract
In our screening of marine actinomycetes for bioactive principles, three novel antibiotics designated as chandrananimycin A (3c), B (3d) and C (4) were isolated from the culture broth of a marine Actinomadura sp. isolate M045. The structures of the new antibiotics were determined by detailed interpretation of mass, 1D and 2D NMR spectra.
摘要
在我们对海洋放线菌进行生物活性成分筛选的过程中，从一株海洋马杜拉放线菌属菌株M045的培养液中分离出了三种新型抗生素，分别命名为钱德拉纳霉素A（3c）、B（3d）和C（4）。通过对质谱、一维和二维核磁共振谱的详细解析确定了这些新型抗生素的结构。
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