Peppa Melpomeni, Uribarri Jaime, Vlassara Helen
Division of Experimental Diabetes and Aging, The Mount Sinai School of Medicine, One Gustave Levy Place, Box 1640, New York, NY 10029, USA.
Curr Diab Rep. 2004 Feb;4(1):31-6. doi: 10.1007/s11892-004-0008-6.
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Atherosclerosis constitutes the main pattern of cardiovascular disease and leads to thickening of the intima with plaque formation and eventual occlusion of the arterial lumen. A large amount of evidence links advanced glycation end products (AGEs) with the development or progression of atherosclerosis, regardless of the diabetic status. AGEs are a heterogenous group of compounds formed by the nonenzymatic reaction of reducing sugars with proteins, lipids, and nucleic acids. Although AGEs are formed endogenously in the body, diet has recently been recognized as an important exogenous source. An increased understanding of the mechanisms of formation and interaction of AGEs has allowed the development of several potential anti-AGE approaches.
心血管疾病（CVD）是全球范围内主要的死亡原因。动脉粥样硬化是心血管疾病的主要形式，会导致内膜增厚并形成斑块，最终使动脉管腔闭塞。大量证据表明，无论糖尿病状态如何，晚期糖基化终末产物（AGEs）都与动脉粥样硬化的发生或发展有关。AGEs是由还原糖与蛋白质、脂质和核酸发生非酶促反应形成的一组异质性化合物。虽然AGEs在体内是内源性形成的，但最近人们认识到饮食是重要的外源性来源。对AGEs形成和相互作用机制的深入了解，已促成了几种潜在抗AGE方法的开发。
