Heldner Mirjam R, Kaufmann-Ezra Sigal, Gutbrod Klemens, Bernasconi Corrado, Bigi Sandra, Blatter Verena, Mattle Heinrich P, Müri René M, Verma Rajeev K, Kamm Christian P
Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
University Neurorehabilitation, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Front Neurol. 2017 Aug 28;8:437. doi: 10.3389/fneur.2017.00437. eCollection 2017.
Behavioral changes are common in patients with multiple sclerosis (MS), however not as readily recognized as cognitive impairments.
The aim of this study was to analyze behavioral changes and its relation to disease characteristics, disability, and cognitive impairments in patients with MS.
This is a single-center cross-sectional study. A detailed neuropsychological examination, including the Frontal Systems Behavior Scale (FrSBe), the Beck depression inventory (BDI), and the Wuerzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS) test, was performed. FrSBe results were correlated with disease characteristics, disability, and cognitive assessments.
66 patients were enrolled (mean age: 43.4 years; disease duration: 9.3 years; Expanded Disability Status Scale: 3.0). Up to one third of patients showed behavioral changes in at least one domain or the total score of the FrSBe. Patients were mildly affected with regard to cognitive functioning. Consistent correlation was found between behavioral changes and fatigue (WEIMuS) and depressive symptoms (BDI), but not with disease characteristics, disability, or cognitive functions. There was an increase of behavioral changes on all FrSBe scales in the current status compared to the retrospectively rated status before disease onset. Self- and family ratings with regard to current behavioral changes were similar.
Behavioral changes are common in otherwise mildly affected MS patients with up to one third being affected. In this patient cohort, behavioral changes occur largely independent of disease characteristics, physical disability, and cognitive functioning but correlate with both fatigue and depressive symptoms. Therefore, they should be tested specifically.
行为改变在多发性硬化症（MS）患者中很常见，但不像认知障碍那样容易被识别。
本研究旨在分析MS患者的行为改变及其与疾病特征、残疾和认知障碍的关系。
这是一项单中心横断面研究。进行了详细的神经心理学检查，包括额叶系统行为量表（FrSBe）、贝克抑郁量表（BDI）和维尔茨堡多发性硬化症疲劳量表（WEIMuS）测试。FrSBe结果与疾病特征、残疾和认知评估相关。
纳入66例患者（平均年龄：43.4岁；病程：9.3年；扩展残疾状态量表：3.0）。高达三分之一的患者在FrSBe的至少一个领域或总分中表现出行为改变。患者的认知功能受到轻度影响。发现行为改变与疲劳（WEIMuS）和抑郁症状（BDI）之间存在一致的相关性，但与疾病特征、残疾或认知功能无关。与疾病发作前的回顾性评分状态相比，当前状态下所有FrSBe量表的行为改变均有所增加。关于当前行为改变的自我评分和家庭评分相似。
行为改变在其他方面轻度受影响的MS患者中很常见，高达三分之一的患者受到影响。在这个患者队列中，行为改变在很大程度上独立于疾病特征、身体残疾和认知功能，但与疲劳和抑郁症状均相关。因此，应进行专门测试。
