Lin Lie-Chwen, Chiou Wen-Fei, Chou Cheng-Jen
National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC.
Planta Med. 2004 Jan;70(1):50-3. doi: 10.1055/s-2004-815455.
Two new phenylpropanoid glycosides, caerulescenoside ( 1), and 3'-methyl crenatoside ( 2), as well as five known phenylpropanoid glycosides [acteoside ( 3), isoacteoside ( 4), campneoside II ( 5), crenatoside ( 6), and desrhamnosyl acteoside ( 7)] were isolated from the whole plant of Orobanche caerulescens. The antioxidative effects of compounds 1 - 7 on human low-density lipoprotein were evaluated. All these compounds suppress concentration-dependently conjugated diene formation with IC (50) values of 1.25 +/- 0.06, 2.97 +/- 0.31, 0.31 +/- 0.01, 1.01 +/- 0.05, 1.15 +/- 0.04, 1.69 +/- 0.15, and 0.64 +/- 0.03 microM, respectively. Comparison of their antioxidative activities with that of resveratrol (IC (50) : 6.75 +/- 1.05 microM), a natural phenolic antioxidant isolated from grape, demonstrated that the prolonged effect on lag-time and the damping effect on oxidative rate by compounds 1 - 7 were all more potent.
从列当全草中分离得到两种新的苯丙素苷，即蓝堇苷（1）和3'-甲基马先蒿苷（2），以及五种已知的苯丙素苷[毛蕊花糖苷（3）、异毛蕊花糖苷（4）、樟叶苷II（5）、马先蒿苷（6）和去鼠李糖毛蕊花糖苷（7）]。评估了化合物1 - 7对人低密度脂蛋白的抗氧化作用。所有这些化合物均呈浓度依赖性地抑制共轭二烯的形成，其半数抑制浓度（IC50）值分别为1.25±0.06、2.97±0.31、0.31±0.01、1.01±0.05、1.15±0.04、1.69±0.15和0.64±0.03 microM。将它们的抗氧化活性与从葡萄中分离得到的天然酚类抗氧化剂白藜芦醇（IC50：6.75±1.05 microM）进行比较，结果表明化合物1 - 7对诱导期的延长作用和对氧化速率的抑制作用均更强。
