Antioxidant and 15-lipoxygenase inhibitory activity of rotenoids, isoflavones and phenolic glycosides from Sarcolobus globosus.

作者信息

Wangensteen Helle, Miron Anca, Alamgir Mahiuddin, Rajia Sultana, Samuelsen Anne Berit, Malterud Karl Egil

机构信息

Division of Pharmacognosy, Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P. O. Box 1068 Blindern, N 0316 Oslo, Norway.

出版信息

Fitoterapia. 2006 Jun;77(4):290-5. doi: 10.1016/j.fitote.2006.03.017. Epub 2006 May 15.

From Sarcolobus globosus, two rotenoids (villosinol and 6-oxo-6a,12a-dehydrodeguelin), one isoflavone (genistin) and four phenolic glycosides (vanillic acid 4-O-beta-d-glucoside, glucosyringic acid, tachioside and isotachioside) were identified for the first time from this species. Extracts and compounds from S. globosus were evaluated for their DPPH radical scavenging and 15-lipoxygenase (15-LO) inhibitory activities. All tested rotenoids were found to inhibit 15-LO, while they lacked DPPH radical scavenging effect.