Knox T B, Kay B H, Hall R A, Ryan P A
Queensland Institute of Medical Research, University of Queensland Australian Centre for International and Tropical Health and Nutrition, Post Office Royal Brisbane Hospital, Herston Qld 4029, Australia.
J Med Entomol. 2003 Nov;40(6):950-6. doi: 10.1603/0022-2585-40.6.950.
Australian Aedes aegypti (L.) mosquitoes colonized from the Torres Strait and three mainland localities (Charters Towers, Townsville, and Cairns) were fed on blood suspensions containing dengue virus type 2 (DEN-2) or dengue virus type 4 (DEN-4). Variation was found in oral susceptibility to DEN-2 (59 -99% infection) and DEN-4 (28-79% infection) among Ae. aegypti assayed for virus at 8, 12, 16, or 20 d after ingestion of infected blood. Torres Strait Ae. aegypti were the most susceptible to DEN-2 and were significantly more efficient in transmission to capillary tube at 16 d (76% transmission) than mainland Ae. aegypti populations (20-28% transmission). Torres Strait Ae. aegypti were also the most susceptible to DEN-4, although transmission did not vary significantly from mainland populations at 16 d (12% compared with 0-4%) or 20 d (16% compared with 4-16%). Disseminated infection (i.e., leg infection) with either DEN-2 or DEN-4 was not an accurate predictor of transmission potential. This study demonstrates differences among Australian Ae. aegypti populations in vector competence for DEN-2 and DEN-4. Torres Strait Ae. aegypti were more frequently infected and able to transmit DEN-2 at higher rates than mainland populations. These data indicate that the Torres Strait region is potentially more receptive to dengue transmission than mainland localities, a finding discussed with respect to past outbreaks.
从托雷斯海峡以及澳大利亚大陆的三个地点（查特斯堡、汤斯维尔和凯恩斯）采集的埃及伊蚊，用含有2型登革病毒（DEN - 2）或4型登革病毒（DEN - 4）的血液悬液进行喂养。在摄入感染血液后的第8、12、16或20天对埃及伊蚊进行病毒检测时发现，不同种群的埃及伊蚊对DEN - 2（感染率59 - 99%）和DEN - 4（感染率28 - 79%）的经口易感性存在差异。托雷斯海峡的埃及伊蚊对DEN - 2最为敏感，在第16天向毛细管传播病毒的效率（76%传播率）显著高于澳大利亚大陆的埃及伊蚊种群（20 - 28%传播率）。托雷斯海峡的埃及伊蚊对DEN - 4也最为敏感，不过在第16天（12%，大陆种群为0 - 4%）或第20天（16%，大陆种群为4 - 16%）时，其传播率与大陆种群相比差异不显著。DEN - 2或DEN - 4的播散性感染（即腿部感染）并不能准确预测传播潜力。本研究证明了澳大利亚不同种群的埃及伊蚊在传播DEN - 2和DEN - 4的媒介能力方面存在差异。托雷斯海峡的埃及伊蚊比大陆种群更易感染且能以更高的速率传播DEN - 2。这些数据表明，托雷斯海峡地区可能比澳大利亚大陆地区更容易传播登革热，这一发现结合过去的疫情爆发情况进行了讨论。
