Kang Chung-Jan, Chang Joseph Tung-Chieh, Chen Tsung-Ming, Chen I-How, Liao Chun-Ta
Department of Otolaryngology, Chang Gung Memorial Hospital, Taipei.
Chang Gung Med J. 2003 Nov;26(11):807-12.
The aim of this study was to evaluate the outcome of patients with Verrucous carcinoma (VC) of oral cavity treated at the Chung Gung Memory Hospital with respect to the tumor control rates after surgery, the risk of lymph node metastasis and the role of radiation therapy.
Thirty-eight patients underwent primary treatment for VC of the oral cavity from January 1996 through February 2002. All of the patients had surgery as their primary treatment. In addition, all patients with sufficient details of the therapy and a minimum 1-year follow-up were selected for evaluation of survival and outcomes.
In this study, 94.7% of patients were male and most of them had been exposed to betel nuts, cigarettes, and/or alcohol. The most common site was the buccal mucosa (57.9%), followed by the tongue (13.2%). T3 lesions were the most common type (34.2%). Only two patients had palpable cervical adenopathy during the initial evaluation. Twenty-five patients had free flap for reconstruction. The tumor control rate was 100%. At the time of analysis, no patient had suffered from recurrence in primary site or neck area.
Surgical excision alone was effective for controlling VC, but elective neck dissection was not necessary even in patients in the advanced stages.
本研究旨在评估中坜荣民医院治疗的口腔疣状癌（VC）患者的手术肿瘤控制率、淋巴结转移风险及放射治疗的作用。
1996年1月至2002年2月，38例患者接受口腔VC的初始治疗。所有患者均以手术作为主要治疗方法。此外，选取所有治疗细节充分且随访至少1年的患者评估生存情况及治疗结果。
本研究中，94.7%的患者为男性，且大多数患者有嚼槟榔、吸烟和/或饮酒史。最常见的部位是颊黏膜（57.9%），其次是舌（13.2%）。T3期病变最为常见（34.2%）。初诊时仅有2例患者可触及颈部淋巴结肿大。25例患者采用游离皮瓣修复。肿瘤控制率为100%。分析时，无患者原发部位或颈部出现复发。
单纯手术切除对控制VC有效，即使是晚期患者也无需进行选择性颈清扫术。
