Morse R P, Bennish M L, Darras B T
Department of Pediatrics, Floating Hospital for Infants and Children, Boston, Massachusetts.
Pediatr Neurol. 1992 Nov-Dec;8(6):473-5. doi: 10.1016/0887-8994(92)90013-o.
Eastern equine encephalitis (EEE) virus causes a severe meningoencephalitis with high morbidity and mortality. Despite numerous clinical reports of EEE, there are only 11 patients in whom cranial computed tomographic (CT) findings are described. In 6 patients, CT was normal and in 5 patients diffuse edema was present; none had a focal brain lesion. Based on these reports, it has been suggested that focal findings on CT support the diagnosis of herpes simplex encephalitis rather than EEE. The first patient with serologically-confirmed EEE and a focal lesion demonstrated by cranial CT and magnetic resonance imaging is described; these findings underscore the importance of including EEE in the differential diagnosis of encephalitides that can cause focal brain lesions on neuroimaging.
东部马脑炎（EEE）病毒可引发严重的脑膜脑炎，发病率和死亡率都很高。尽管有大量关于EEE的临床报告，但仅有11例患者的头颅计算机断层扫描（CT）结果被描述。6例患者CT结果正常，5例患者出现弥漫性水肿；均无局灶性脑病变。基于这些报告，有人提出CT上的局灶性表现支持单纯疱疹病毒性脑炎而非EEE的诊断。本文描述了首例经血清学确诊的EEE患者，其头颅CT和磁共振成像显示存在局灶性病变；这些发现强调了在鉴别诊断可在神经影像学上导致局灶性脑病变的脑炎时将EEE纳入考虑的重要性。
