Kobayashi Katsunori, Poo Mu-ming
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Neuron. 2004 Feb 5;41(3):445-54. doi: 10.1016/s0896-6273(03)00873-0.
In the CA3 region of the hippocampus, extensive recurrent associational/commissural (A/C) connections made by pyramidal cells may function as a network for associative memory storage and recall. We here report that long-term potentiation (LTP) at the A/C synapses can be induced by association of brief spike trains in mossy fibers (MFs) from the dentate gyrus and A/C fibers. This LTP not only required substantial overlap between spike trains in MFs and A/C fibers, but also depended on the temporal order of these spike trains in a manner not predicted by the well-known rule of spike timing-dependent plasticity and requiring activation of type 1 metabotropic glutamate receptors. Importantly, spike trains in a putative single MF input provided effective postsynaptic activity for the induction of LTP at A/C synapses. Thus, the timing of spike trains in individual MFs may code information that is crucial for the associative modification of CA3 recurrent synapses.
在海马体的CA3区域，锥体细胞形成的广泛的反复性联合/连合（A/C）连接可能作为一个用于联想记忆存储和回忆的网络。我们在此报告，来自齿状回的苔藓纤维（MFs）和A/C纤维中的短暂脉冲序列联合可诱导A/C突触处的长时程增强（LTP）。这种LTP不仅需要MFs和A/C纤维中的脉冲序列有大量重叠，还以一种著名的脉冲时间依赖性可塑性规则未预测的方式依赖于这些脉冲序列的时间顺序，并且需要1型代谢型谷氨酸受体的激活。重要的是，假定的单个MF输入中的脉冲序列为A/C突触处LTP的诱导提供了有效的突触后活动。因此，单个MFs中脉冲序列的时间可能编码对CA3反复性突触的联想修饰至关重要的信息。
