Sindern Eckhart
Department of Neurology, BG-Kliniken Bergmannsheil, Ruhr-University, Burkle-de-la-Camp-Platz 1, 44789 Bochum, Germany.
Front Biosci. 2004 Jan 1;9:457-63. doi: 10.2741/1238.
Multiple sclerosis (MS) is an autoimmune disease of the human central nervous system (CNS) of unknown etiology that causes demyelination and associated tissue injury. Trafficking of inflammatory T cells into the CNS is a crucial event in the pathogenesis of MS, a process in which chemokines and their receptors have been demonstrated to play an important role. Chemokines are key mediators of inflammation and have major effects on migration of cells to the sites of inflammation as well as activation of recruited and resident CNS cells. This paper summarizes recent and new information about the expression and function of elements of the chemokine system in MS and its animal model experimental allergic encephalomyelitis. Analysis of the chemokine system provides insights into mechanisms of CNS inflammatory reactions and may lead to new targets of therapeutic intervention in MS.
多发性硬化症（MS）是一种病因不明的人类中枢神经系统（CNS）自身免疫性疾病，可导致脱髓鞘及相关组织损伤。炎性T细胞向中枢神经系统的迁移是MS发病机制中的关键事件，在此过程中，趋化因子及其受体已被证明发挥重要作用。趋化因子是炎症的关键介质，对细胞向炎症部位的迁移以及募集和驻留的中枢神经系统细胞的激活具有重大影响。本文总结了关于趋化因子系统各成分在MS及其动物模型实验性自身免疫性脑脊髓炎中的表达和功能的最新信息。对趋化因子系统的分析有助于深入了解中枢神经系统炎症反应的机制，并可能为MS的治疗干预提供新靶点。
