多发性硬化症中的B细胞。
B cells in multiple sclerosis.
作者信息
Burgoon Mark P, Gilden Donald H, Owens Gregory P
机构信息
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
出版信息
Front Biosci. 2004 Jan 1;9:786-96. doi: 10.2741/1278.
Abstract
The most common laboratory abnormality in multiple sclerosis (MS) is an increased amount of cerebrospinal fluid IgG and the presence of oligoclonal bands. Despite studies of the humoral response that suggest the involvement of an infectious agent or autoantigen in disease, the major targets of the oligoclonal response are still unknown. Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment.
摘要
多发性硬化症（MS）最常见的实验室异常是脑脊液中IgG含量增加以及寡克隆带的出现。尽管对体液反应的研究表明病原体或自身抗原参与了疾病，但寡克隆反应的主要靶点仍然未知。确定这些靶点将为MS的病因和发病机制提供有价值的见解，并可能带来有效的治疗方法。
相似文献
1
B cells in multiple sclerosis.多发性硬化症中的B细胞。
Front Biosci. 2004 Jan 1;9:786-96. doi: 10.2741/1278.
2
A Spontaneous Model of Experimental Autoimmune Encephalomyelitis Provides Evidence of MOG-Specific B Cell Recruitment and Clonal Expansion.实验性自身免疫性脑脊髓炎的自发模型提供了 MOG 特异性 B 细胞募集和克隆扩增的证据。
Front Immunol. 2022 Feb 3;13:755900. doi: 10.3389/fimmu.2022.755900. eCollection 2022.
3
The role of B cells and autoantibodies in multiple sclerosis.B细胞和自身抗体在多发性硬化症中的作用。
Ann Neurol. 2000 Jun;47(6):694-706.
4
B cells and multiple sclerosis.B细胞与多发性硬化症
Lancet Neurol. 2008 Sep;7(9):852-8. doi: 10.1016/S1474-4422(08)70192-3.
5
The B cell response in multiple sclerosis.多发性硬化症中的B细胞反应。
Neurol Res. 2006 Apr;28(3):236-44. doi: 10.1179/016164106X98099.
6
Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness.多发性硬化症脑脊液中的寡克隆带：方法学与临床应用的最新进展
J Neuroimmunol. 2006 Nov;180(1-2):17-28. doi: 10.1016/j.jneuroim.2006.07.006. Epub 2006 Sep 1.
7
B Cells and Autoantibodies in Multiple Sclerosis.多发性硬化症中的B细胞与自身抗体
Int J Mol Sci. 2015 Jul 21;16(7):16576-92. doi: 10.3390/ijms160716576.
8
Roles of immunoglobulins and B cells in multiple sclerosis: from pathogenesis to treatment.免疫球蛋白和B细胞在多发性硬化症中的作用：从发病机制到治疗
J Neuroimmunol. 2006 Nov;180(1-2):3-8. doi: 10.1016/j.jneuroim.2006.06.032. Epub 2006 Aug 23.
9
The role of B cells in multiple sclerosis: rationale for B-cell-targeted therapies.B细胞在多发性硬化症中的作用：B细胞靶向治疗的理论依据。
Curr Opin Neurol. 2008 Apr;21 Suppl 1:S9-S18. doi: 10.1097/01.wco.0000313359.61176.15.
10
Multiplexing approaches for autoantibody profiling in multiple sclerosis.用于多发性硬化症自身抗体分析的多重检测方法。
Autoimmun Rev. 2009 Jun;8(7):573-9. doi: 10.1016/j.autrev.2009.02.001. Epub 2009 Feb 9.
引用本文的文献
1
Role of SIRT1 in autoimmune demyelination and neurodegeneration.SIRT1在自身免疫性脱髓鞘和神经退行性变中的作用。
Immunol Res. 2015 Mar;61(3):187-97. doi: 10.1007/s12026-014-8557-5.
2
Pathology of multiple sclerosis: where do we stand?多发性硬化症的病理学：我们目前的进展如何？
Continuum (Minneap Minn). 2013 Aug;19(4 Multiple Sclerosis):901-21. doi: 10.1212/01.CON.0000433291.23091.65.
3
Recombinant antibodies generated from both clonal and less abundant plasma cell immunoglobulin G sequences in subacute sclerosing panencephalitis brain are directed against measles virus.在亚急性硬化性全脑炎大脑中，从克隆性和丰度较低的浆细胞免疫球蛋白G序列产生的重组抗体是针对麻疹病毒的。
J Neurovirol. 2006 Oct;12(5):398-402. doi: 10.1080/13550280600957414.
4
Laser-capture microdissection of plasma cells from subacute sclerosing panencephalitis brain reveals intrathecal disease-relevant antibodies.对亚急性硬化性全脑炎大脑中的浆细胞进行激光捕获显微切割，发现鞘内存在与疾病相关的抗体。
Proc Natl Acad Sci U S A. 2005 May 17;102(20):7245-50. doi: 10.1073/pnas.0502323102. Epub 2005 May 9.
本文引用的文献
1
Notice of retraction: "Multiple sclerosis and Epstein-Barr virus" (JAMA. 2003;289:1533-1536).撤稿通知：《多发性硬化症与爱泼斯坦-巴尔病毒》（《美国医学会杂志》。2003年；289:1533 - 1536）。
JAMA. 2005 May 25;293(20):2466. doi: 10.1001/jama.293.20.2466-a.
2
Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV.水痘带状疱疹病毒（VZV）血管病变时脑脊液中的寡克隆免疫球蛋白针对VZV。
Ann Neurol. 2003 Oct;54(4):459-63. doi: 10.1002/ana.10685.
3
Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid.单细胞谱系分析表明，克隆性扩增是多发性硬化症脑脊液中B细胞反应的一个显著特征。
J Immunol. 2003 Sep 1;171(5):2725-33. doi: 10.4049/jimmunol.171.5.2725.
4
Endogenous retroviruses and MS: using ERVs as disease markers.内源性逆转录病毒与多发性硬化症：将内源性逆转录病毒用作疾病标志物
Int MS J. 2003 Apr;10(1):22-8.
5
Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis.鞘内B细胞克隆性扩增是体液免疫的早期迹象，存在于疑似多发性硬化症的临床孤立综合征患者的脑脊液中。
Lab Invest. 2003 Jul;83(7):1081-8. doi: 10.1097/01.lab.0000077008.24259.0d.
6
Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event.抗髓鞘抗体作为首次脱髓鞘事件后临床确诊多发性硬化症的预测指标。
N Engl J Med. 2003 Jul 10;349(2):139-45. doi: 10.1056/NEJMoa022328.
7
Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions.多发性硬化症患者血清和脑脊液中的髓鞘碱性蛋白反应性自身抗体具有低亲和力相互作用的特征。
J Neuroimmunol. 2003 Mar;136(1-2):140-8. doi: 10.1016/s0165-5728(03)00002-x.
8
Antibodies against a human endogenous retrovirus and the preponderance of env splice variants in multiple sclerosis patients.针对人类内源性逆转录病毒的抗体以及多发性硬化症患者中env剪接变体的优势
Mult Scler. 2003 Feb;9(1):6-15. doi: 10.1191/1352458503ms867oa.
9
The proteasome is a major autoantigen in multiple sclerosis.蛋白酶体是多发性硬化症中的一种主要自身抗原。
Brain. 2002 Dec;125(Pt 12):2658-67. doi: 10.1093/brain/awf274.
10
Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis.
Eur J Neurol. 2002 May;9(3):243-51. doi: 10.1046/j.1468-1331.2002.00391.x.
Zotero 插件