Burgoon Mark P, Caldas Yupanqui A, Keays Kathryne M, Yu Xiaoli, Gilden Donald H, Owens Gregory P
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
J Neurovirol. 2006 Oct;12(5):398-402. doi: 10.1080/13550280600957414.
Increased immunoglobulin G (IgG) and intrathecally produced oligoclonal bands (OGBs) are characteristic of a limited number of inflammatory central nervous system (CNS) diseases and are often directed against the cause of disease. In subacute sclerosing panencephalitis (SSPE), the cause of disease and the target of the oligoclonal response is measles virus (MV). The authors previously showed that clonally expanded populations of CD38+ plasma cells in SSPE brain, the likely source of OGBs, are directed against MV. In characterizing the breadth of the plasma cell reactivities, the authors found that a large proportion of the less abundant plasma cells are also directed against MV. The intrathecal response may be useful in determining the causes of other inflammatory CNS diseases, such as multiple sclerosis, Behcet's disease, and neurosarcoidosis.
免疫球蛋白G（IgG）升高和鞘内产生的寡克隆带（OGBs）是少数炎症性中枢神经系统（CNS）疾病的特征，且通常针对疾病病因。在亚急性硬化性全脑炎（SSPE）中，疾病病因及寡克隆反应的靶点是麻疹病毒（MV）。作者之前表明，SSPE脑内克隆性扩增的CD38 +浆细胞群体（可能是OGBs的来源）针对MV。在表征浆细胞反应性的广度时，作者发现，很大一部分数量较少的浆细胞也针对MV。鞘内反应可能有助于确定其他炎症性CNS疾病的病因，如多发性硬化症、白塞病和神经结节病。
