水痘带状疱疹病毒（VZV）血管病变时脑脊液中的寡克隆免疫球蛋白针对VZV。
Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV.
作者信息
Burgoon Mark P, Hammack Barbara N, Owens Gregory P, Maybach Amy L, Eikelenboom M Judith, Gilden Donald H
机构信息
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
出版信息
Ann Neurol. 2003 Oct;54(4):459-63. doi: 10.1002/ana.10685.
Abstract
Limited analyses of cerebrospinal fluid from patients with central nervous system infections have shown that the oligoclonal IgG is antibody directed against the agent that causes disease. Using a new method involving binding of IgG to beads coated with lysates prepared from candidate infectious antigens, we showed that the oligoclonal IgG in cerebrospinal fluid of a patient with chronic varicella zoster virus vasculopathy is directed against the causative virus. This approach holds promise in identifying and purifying the relevant oligoclonal IgGs in inflammatory central nervous system diseases of unknown cause.
摘要
对中枢神经系统感染患者脑脊液的有限分析表明，寡克隆IgG是针对致病病原体的抗体。我们采用一种新方法，即将IgG与包被有候选感染性抗原制备的裂解物的珠子结合，结果显示，一名患有慢性水痘带状疱疹病毒血管病患者脑脊液中的寡克隆IgG是针对致病病毒的。这种方法有望用于鉴定和纯化病因不明的炎症性中枢神经系统疾病中的相关寡克隆IgG。
相似文献
1
Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV.水痘带状疱疹病毒（VZV）血管病变时脑脊液中的寡克隆免疫球蛋白针对VZV。
Ann Neurol. 2003 Oct;54(4):459-63. doi: 10.1002/ana.10685.
2
Unusual presentation of central nervous system manifestations of Varicella zoster virus vasculopathy in renal transplant recipients.肾移植受者水痘带状疱疹病毒血管病中枢神经系统表现的不寻常呈现。
Transpl Infect Dis. 2007 Sep;9(3):237-40. doi: 10.1111/j.1399-3062.2006.00190.x.
3
Polymerase chain reaction analysis and oligoclonal antibody in the cerebrospinal fluid from 34 patients with varicella-zoster virus infection of the nervous system.34例神经系统水痘-带状疱疹病毒感染患者脑脊液的聚合酶链反应分析及寡克隆抗体检测
J Neurol Neurosurg Psychiatry. 2006 Aug;77(8):938-42. doi: 10.1136/jnnp.2006.090316. Epub 2006 Apr 25.
4
Antibody-capture enzyme-linked immunosorbent assays that use enzyme-labelled antigen for detection of virus-specific immunoglobulin M, A and G in patients with varicella or herpes zoster.抗体捕获酶联免疫吸附测定法，该方法使用酶标记抗原检测水痘或带状疱疹患者体内的病毒特异性免疫球蛋白M、A和G。
Epidemiol Infect. 1992 Feb;108(1):165-74. doi: 10.1017/s095026880004961x.
5
Multifocal vasculopathy due to Varicella-Zoster Virus (VZV): serial analysis of VZV DNA and intrathecal synthesis of VZV antibody in cerebrospinal fluid.水痘-带状疱疹病毒（VZV）引起的多灶性血管病：脑脊液中VZV DNA的系列分析及VZV抗体的鞘内合成
Clin Infect Dis. 2002 Aug 1;35(3):330-3. doi: 10.1086/341492. Epub 2002 Jul 8.
6
7
Multiple sclerosis. Electrofocused "bands" of oligoclonal CSF IgG do not carry antibody activity against measles, varicella-zoster or rotaviruses.多发性硬化症。寡克隆脑脊液IgG的电聚焦“条带”不携带针对麻疹、水痘-带状疱疹或轮状病毒的抗体活性。
J Neurol Sci. 1982 Apr;54(1):99-107. doi: 10.1016/0022-510x(82)90222-2.
8
Immunoglobulins M and G to varicella-zoster virus measured by solid-phase radioimmunoassay: antibody responses to varicella and herpes zoster infections.通过固相放射免疫测定法检测的针对水痘-带状疱疹病毒的免疫球蛋白M和G：对水痘和带状疱疹感染的抗体反应
J Clin Microbiol. 1980 Sep;12(3):367-74. doi: 10.1128/jcm.12.3.367-374.1980.
9
Aseptic meningitis due to varicella-zoster virus: serum antibody levels and local synthesis of specific IgG, IgM, and IgA.水痘-带状疱疹病毒所致无菌性脑膜炎：血清抗体水平及特异性IgG、IgM和IgA的局部合成
J Infect Dis. 1987 May;155(5):959-67. doi: 10.1093/infdis/155.5.959.
10
Reactivity of varicella-zoster virus subunit antigens in enzyme-linked immunosorbent assay to sera from varicella, zoster, and herpes simplex virus infections.水痘-带状疱疹病毒亚单位抗原在酶联免疫吸附试验中对水痘、带状疱疹及单纯疱疹病毒感染患者血清的反应性。
Med Microbiol Immunol. 1994 Feb;183(1):1-11. doi: 10.1007/BF00193626.
引用本文的文献
1
Autoimmune Ataxia During Maintenance Therapy for Acute Lymphoblastic Leukemia.急性淋巴细胞白血病维持治疗期间的自身免疫性共济失调
Child Neurol Open. 2018 Dec 16;5:2329048X18819235. doi: 10.1177/2329048X18819235. eCollection 2018.
2
A Neuroprimer: Principles of Central Nervous System Immunity.神经基础：中枢神经系统免疫原理
Semin Pediatr Neurol. 2017 Aug;24(3):145-151. doi: 10.1016/j.spen.2017.08.004. Epub 2017 Aug 14.
3
Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants.多发性硬化症脑脊液中克隆扩增的浆细胞产生的抗体导致脊髓外植体脱髓鞘。
Acta Neuropathol. 2015 Dec;130(6):765-81. doi: 10.1007/s00401-015-1500-6. Epub 2015 Oct 28.
4
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.浸润多发性硬化症脑部的B细胞在引流性颈部淋巴结中成熟。
Sci Transl Med. 2014 Aug 6;6(248):248ra107. doi: 10.1126/scitranslmed.3008879.
5
Viruses and multiple sclerosis.病毒与多发性硬化。
Neuroscientist. 2011 Dec;17(6):659-76. doi: 10.1177/1073858411386615.
6
Review: The neurobiology of varicella zoster virus infection.综述：水痘-带状疱疹病毒感染的神经生物学。
Neuropathol Appl Neurobiol. 2011 Aug;37(5):441-63. doi: 10.1111/j.1365-2990.2011.01167.x.
7
Efficacy of live zoster vaccine in preventing zoster and postherpetic neuralgia.带状疱疹疫苗预防带状疱疹和疱疹后神经痛的疗效。
J Intern Med. 2011 May;269(5):496-506. doi: 10.1111/j.1365-2796.2011.02359.x. Epub 2011 Feb 23.
8
Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis.多发性硬化症患者的脑组织和脑脊液中不存在 Epstein-Barr 病毒。
Neurology. 2010 Apr 6;74(14):1127-35. doi: 10.1212/WNL.0b013e3181d865a1. Epub 2010 Mar 10.
9
Virus vasculopathy and stroke: an under-recognized cause and treatment target.病毒血管病变与中风：一种未被充分认识的病因及治疗靶点。
Infect Disord Drug Targets. 2010 Apr;10(2):105-11. doi: 10.2174/187152610790963537.
10
Clinical and molecular aspects of varicella zoster virus infection.水痘带状疱疹病毒感染的临床和分子学方面
Future Neurol. 2009 Jan 1;4(1):103-117. doi: 10.2217/14796708.4.1.103.
本文引用的文献
1
Two patients with unusual forms of varicella-zoster virus vasculopathy.两名患有不寻常形式水痘带状疱疹病毒血管病的患者。
N Engl J Med. 2002 Nov 7;347(19):1500-3. doi: 10.1056/NEJMoa020841.
2
A sensitive and reproducible method for the detection of oligoclonal IgM bands.一种检测寡克隆IgM带的灵敏且可重复的方法。
J Immunol Methods. 2001 Dec 1;258(1-2):151-5. doi: 10.1016/s0022-1759(01)00492-6.
3
Cloning the antibody response in humans with inflammatory CNS disease: isolation of measles virus-specific antibodies from phage display libraries of a subacute sclerosing panencephalitis brain.克隆患有炎症性中枢神经系统疾病的人类的抗体反应：从亚急性硬化性全脑炎大脑的噬菌体展示文库中分离麻疹病毒特异性抗体。
J Neuroimmunol. 1999 Feb 1;94(1-2):204-11. doi: 10.1016/s0165-5728(98)00243-4.
4
The search for virus in multiple sclerosis brain.在多发性硬化症患者大脑中寻找病毒。
Mult Scler. 1996 Nov;2(4):179-83. doi: 10.1177/135245859600200403.
5
Characterization of immune complexes in progressive rubella panencephalitis.
Ann Neurol. 1981 Jun;9(6):557-62. doi: 10.1002/ana.410090608.
6
Neurosyphilis: intrathecal synthesis of oligoclonal antibodies to Treponema pallidum.神经梅毒：针对梅毒螺旋体的寡克隆抗体的鞘内合成。
Ann Neurol. 1982 Jan;11(1):35-40. doi: 10.1002/ana.410110107.
7
8
HTLV-I-associated myelopathy: oligoclonal immunoglobulin G bands contain anti-HTLV-I p24 antibody.
Ann Neurol. 1988 Dec;24(6):727-31. doi: 10.1002/ana.410240606.
9
An isoelectric focusing study in herpes simplex virus encephalitis.
Ann Neurol. 1988 Aug;24(2):227-32. doi: 10.1002/ana.410240209.
10
Chronic progressive myelopathy associated with HTLV-I: oligoclonal IgG and anti-HTLV-I IgG antibodies in cerebrospinal fluid and serum.
Neurology. 1989 Dec;39(12):1566-72. doi: 10.1212/wnl.39.12.1566.
Zotero 插件