水痘带状疱疹病毒（VZV）血管病变时脑脊液中的寡克隆免疫球蛋白针对VZV。
Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV.
作者信息
Burgoon Mark P, Hammack Barbara N, Owens Gregory P, Maybach Amy L, Eikelenboom M Judith, Gilden Donald H
机构信息
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
出版信息
Ann Neurol. 2003 Oct;54(4):459-63. doi: 10.1002/ana.10685.
Abstract
Limited analyses of cerebrospinal fluid from patients with central nervous system infections have shown that the oligoclonal IgG is antibody directed against the agent that causes disease. Using a new method involving binding of IgG to beads coated with lysates prepared from candidate infectious antigens, we showed that the oligoclonal IgG in cerebrospinal fluid of a patient with chronic varicella zoster virus vasculopathy is directed against the causative virus. This approach holds promise in identifying and purifying the relevant oligoclonal IgGs in inflammatory central nervous system diseases of unknown cause.
摘要
对中枢神经系统感染患者脑脊液的有限分析表明，寡克隆IgG是针对致病病原体的抗体。我们采用一种新方法，即将IgG与包被有候选感染性抗原制备的裂解物的珠子结合，结果显示，一名患有慢性水痘带状疱疹病毒血管病患者脑脊液中的寡克隆IgG是针对致病病毒的。这种方法有望用于鉴定和纯化病因不明的炎症性中枢神经系统疾病中的相关寡克隆IgG。
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