过敏性疾病中血清胸腺和活化调节趋化因子（TARC）及皮肤T细胞吸引趋化因子（CTACK）水平：TARC和CTACK是特应性皮炎的疾病特异性标志物。

Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis.

作者信息

Hijnen DirkJan, De Bruin-Weller Marjolein, Oosting Bert, Lebre Cristina, De Jong Esther, Bruijnzeel-Koomen Carla, Knol Edward

机构信息

Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The, Netherlands.

出版信息

J Allergy Clin Immunol. 2004 Feb;113(2):334-40. doi: 10.1016/j.jaci.2003.12.007.

DOI:10.1016/j.jaci.2003.12.007

PMID:14767451

Abstract

BACKGROUND

Tissue infiltration of CD4(+) T cells plays an important role in the pathogenesis of allergic diseases. T-cell trafficking is mediated by specific chemokines and their receptors.

OBJECTIVE

The purpose of this study was to investigate the participation of the chemokines thymus and activation-regulated chemokine (TARC) and cutaneous T cell-attracting chemokine (CTACK) in a large population of patients with allergic diseases.

METHODS

Serum TARC and CTACK levels were measured in 455 patients with allergic disease. Patients were characterized as having atopic dermatitis (AD), allergic asthma, allergic rhinitis, or combinations or as healthy control subjects. Serum TARC and CTACK levels were correlated with disease activity in patients with AD. Furthermore, in 7 patients with AD, serum TARC and CTACK levels were studied after the start of systemic cyclosporin A treatment. Finally, TARC and CTACK localization was checked by immunohistochemistry in lesional skin biopsy specimens of patients with AD.

RESULTS

Both TARC and CTACK serum levels in patients with AD were significantly higher than those in healthy control subjects and patients with allergic respiratory disease. Furthermore, serum TARC and CTACK levels significantly correlated with disease activity in patients with AD. Serum TARC levels paralleled clinical improvement in patients treated with cyclosporin A. Immunoreactive TARC was found in infiltrating cells and endothelial cells of the dermis but not in epidermal cells.

CONCLUSIONS

The serum TARC level is an objective parameter for disease severity specific for AD. Furthermore, it is a promising tool for treatment monitoring.

摘要

背景

CD4(+) T细胞的组织浸润在过敏性疾病的发病机制中起重要作用。T细胞迁移由特定的趋化因子及其受体介导。

目的

本研究旨在调查趋化因子胸腺和活化调节趋化因子（TARC）及皮肤T细胞吸引趋化因子（CTACK）在大量过敏性疾病患者中的参与情况。

方法

测定了455例过敏性疾病患者的血清TARC和CTACK水平。患者被分为患有特应性皮炎（AD）、过敏性哮喘、过敏性鼻炎或其组合，或作为健康对照受试者。AD患者的血清TARC和CTACK水平与疾病活动度相关。此外，对7例AD患者在开始全身应用环孢素A治疗后研究了血清TARC和CTACK水平。最后，通过免疫组织化学检查AD患者皮损活检标本中的TARC和CTACK定位。