Hadaya K, Kaiser L, Rubbia-Brandt L, Gervaix A, Diana A
Central Laboratory of Virology, Division of Infectious Diseases, Department of Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Eur J Clin Microbiol Infect Dis. 2004 Mar;23(3):218-20. doi: 10.1007/s10096-003-1079-z. Epub 2004 Feb 7.
Described here is the unusual case of a previously healthy 17-month-old girl who developed severe cytomegalovirus (CMV) disease with prolonged fever and hepatitis. The severity of her illness required hospitalization and prompted antiviral treatment. Short-term intravenous ganciclovir treatment was associated with immediate and sustained resolution of the symptoms as well as a sharp decrease of CMV viremia. This observation suggests that antiviral therapy might be considered in select cases of severe primary CMV infection in immunocompetent children.
本文描述了一名17个月大的既往健康女童的罕见病例，她患上了伴有持续发热和肝炎的严重巨细胞病毒（CMV）疾病。其病情严重程度需要住院治疗，并促使进行抗病毒治疗。短期静脉注射更昔洛韦治疗使症状迅速且持续缓解，同时CMV病毒血症急剧下降。这一观察结果表明，对于免疫功能正常儿童的某些严重原发性CMV感染病例，可能应考虑抗病毒治疗。
