Fernández-Ruiz Mario, Muñoz-Codoceo Carolina, López-Medrano Francisco, Faré-García Regina, Carbonell-Porras Amparo, Garfia-Castillo Cristina, Muñoz-Gómez Raquel, Aguado-García Jose María
Department of Internal Medicine, University Hospital 12 de Octubre, Madrid, Spain.
Intern Med. 2008;47(22):1963-6. doi: 10.2169/internalmedicine.47.1480. Epub 2008 Nov 17.
Primary infection by cytomegalovirus (CMV) commonly occurs subclinically or manifested by a self-limited mononucleosis-like syndrome in immunocompetent subjects. Severe clinical pictures are uncommon. We present a case of acute myopericarditis and hepatitis in a previously healthy 32-year-old man with primary CMV infection, assessed by serology and positive pp65 antigenemia. He was successfully treated with a course of oral valganciclovir therapy, with an immediate clinical response and normalization of laboratory tests. The literature on simultaneous presentation of CMV pericarditis and hepatitis in immunocompetent hosts, as well as the role of oral valganciclovir in this clinical setting, is reviewed.
巨细胞病毒（CMV）的原发性感染在免疫功能正常的个体中通常呈亚临床状态，或表现为自限性单核细胞增多症样综合征。严重的临床表现并不常见。我们报告一例先前健康的32岁男性原发性CMV感染并发急性心肌心包炎和肝炎的病例，通过血清学和pp65抗原血症阳性进行评估。他接受了一个疗程的口服缬更昔洛韦治疗，临床症状迅速缓解，实验室检查结果恢复正常。本文对免疫功能正常宿主中同时出现CMV心包炎和肝炎的相关文献，以及口服缬更昔洛韦在这种临床情况下的作用进行了综述。
