Odaka T, Ikeda H, Akatsuka T
Institute of Medical Science, Shirokanedai 4-6-1, Minato-ku, Tokyo 108, Japan.
Int J Cancer. 1980 Jun 15;25(6):757-62. doi: 10.1002/ijc.2910250611.
G mice carrying the Fv-4r gene are resistant to exogenous infections of various strains of ecotropic MuLVs (Suzuki, 1975). The expression of endogenous N-tropic XC-positive virus was studied in the progency of a cross between G and AKR mice. In the F1 mice, the virus expression was almost completely supressed, and no leukemia developed during 1 year of observation. Results of successive backcrossings with AKR mice indicated that a single dominant gene, the Fv-4r suffices for supression. It can be concluded that the extensive growth of N-tropic XC-positive virus is a prerequisite for leukemia development in AKR mice.
携带Fv - 4r基因的G小鼠对外源嗜亲性MuLVs各毒株的感染具有抗性（铃木，1975年）。在G小鼠和AKR小鼠杂交后代中研究了内源性嗜N性XC阳性病毒的表达情况。在F1代小鼠中，病毒表达几乎被完全抑制，并且在1年的观察期内没有白血病发生。与AKR小鼠连续回交的结果表明，单个显性基因Fv - 4r足以实现抑制作用。可以得出结论，嗜N性XC阳性病毒的广泛生长是AKR小鼠白血病发生的先决条件。
