高甘油三酯腰围男性的心血管危险因素（德黑兰血脂与血糖研究）

Cardiovascular risk factors in males with hypertriglycemic waist (Tehran Lipid and Glucose Study).

作者信息

Solati M, Ghanbarian A, Rahmani M, Sarbazi N, Allahverdian S, Azizi F

机构信息

Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Int J Obes Relat Metab Disord. 2004 May;28(5):706-9. doi: 10.1038/sj.ijo.0802582.

DOI:10.1038/sj.ijo.0802582

PMID:14770189

Abstract

BACKGROUND

Many studies performed on nontraditional risk factors have proposed a metabolic triad including increased serum level of apolipoprotein B, hyperinsulinemia and high small, dense LDL-C as a risk factor of cardiovascular diseases. Hypertriglycemic waist (increased waist circumference as well as high fasting triglyceride level) can be used as a simple criterion to predict the metabolic triad. The aim of this study was to investigate the prevalence of hypertriglycemic waist and the frequency of cardiovascular risk factors in the affected population.

MATERIALS AND METHODS

The study was performed on 4169, 18-70 y-old male subjects of the population of Tehran Lipid and Glucose Study (TLGS). The subjects fell into four groups with respect to serum level of fasting triglycerides (Tg) and waist circumference (WC). Subjects of group 1 had serum Tg > or =1.8 mmol/l as well as WC > or =95 cm, while those of group 2 had Tg > or =1.8 mmol/l and WC <95 cm. The triglycerides level was less than 1.8 mmol/l in groups 3 and 4, whereas WC was > or =95 cm and lower than 95 cm, respectively. Cardiovascular risk factors, anthropometric and laboratory variables were compared between the groups.

RESULTS

In total, 784 subjects had high serum levels of Tg as well as increased WC. The mean age of subjects was significantly higher in groups 1 and 3 compared to others (37+/-15, 48+/-14, 41+13 and 46+/-13 y of age in groups 4, 3, 2 and 1, respectively, P<0.001). The prevalence of cardiovascular risk factors was significantly higher in group 1 as compared with others. Systolic and diastolic blood pressure, body mass index and WC were significantly higher in group 1 than in the others. Serum total cholesterol, Tg and LDL-C were significantly higher in group 1 compared to others, whereas HDL-C was significantly lower in this group. The prevalence of subjects who had at least four risk factors was 75 and 8% in groups 1 and 4, respectively.

CONCLUSION

Hypertriglycemic waist can be used as a simple criterion to predict cardiovascular risk factors.

摘要

背景

许多针对非传统风险因素开展的研究提出了一种代谢三联征，包括血清载脂蛋白B水平升高、高胰岛素血症以及高比例的小而密低密度脂蛋白胆固醇，将其作为心血管疾病的一个风险因素。高甘油三酯腰围（腰围增加以及空腹甘油三酯水平升高）可作为预测代谢三联征的一个简单标准。本研究的目的是调查高甘油三酯腰围的患病率以及受影响人群中心血管风险因素的发生频率。

材料与方法

本研究以德黑兰血脂与血糖研究（TLGS）中4169名年龄在18至70岁的男性受试者为对象。根据空腹甘油三酯（Tg）血清水平和腰围（WC），受试者分为四组。第1组受试者的血清Tg≥1.8 mmol/l且WC≥95 cm，而第2组受试者的Tg≥1.8 mmol/l且WC<95 cm。第3组和第4组的甘油三酯水平低于1.8 mmol/l，而WC分别≥95 cm和低于95 cm。对各组之间的心血管风险因素、人体测量和实验室变量进行了比较。

结果

总共有784名受试者的血清Tg水平高且WC增加。与其他组相比，第1组和第3组受试者的平均年龄显著更高（第4、3、2和1组的年龄分别为37±15、48±14、41±13和46±13岁，P<0.001）。与其他组相比，第1组中心血管风险因素的患病率显著更高。第1组的收缩压和舒张压、体重指数和WC显著高于其他组。与其他组相比，第1组的血清总胆固醇、Tg和低密度脂蛋白胆固醇显著更高，而该组的高密度脂蛋白胆固醇显著更低。至少有四个风险因素的受试者在第1组和第4组中的患病率分别为75%和8%。