Calzetti S, Sasso E, Baratti M, Fava R
Institute of Neurology, University of Parma, Italy.
Acta Neurol Scand. 1990 May;81(5):392-6. doi: 10.1111/j.1600-0404.1990.tb00982.x.
Despite a large number of studies demonstrating the effectiveness of propranolol in relieving essential tremor (ET) the long-term therapeutic outcome of these patients remains poorly defined. The results of a one-year follow-up study in 18 patients with mild to severe ET performed by using clinical and computer-based methods of assessment indicate that the initial therapeutic benefit of propranolol is apparently retained. However, following 3-6 months of sustained treatment a proportion of patients required an increase in daily dosage of propranolol in order to maintain adequate symptomatic control of tremor, indicating a relative decrease in tremorolytic efficacy of the drug possibly due to long-term tolerance.
尽管大量研究表明普萘洛尔在缓解特发性震颤（ET）方面有效，但这些患者的长期治疗结果仍不明确。一项对18例轻至重度ET患者进行的为期一年的随访研究结果表明，使用临床和基于计算机的评估方法，普萘洛尔的初始治疗益处显然得以保留。然而，在持续治疗3 - 6个月后，一部分患者需要增加普萘洛尔的每日剂量以维持对震颤的充分症状控制，这表明该药物的震颤溶解功效可能因长期耐受而相对降低。
