Ferrara L A, Iannuzzi R, Castaldo A, Iannuzzi A, Dello Russo A, Mancini M
Institute of Internal Medicine, 2nd Medical School, University of Naples, Italy.
Cardiology. 1992;81(1):25-33. doi: 10.1159/000175772.
The main objective of this clinical trial was to evaluate the effects of magnesium pidolate (15 mmol/day) on blood pressure at rest and during sympathetic stimulation induced by cold, isometric and tilt test; peripheral blood flow has been evaluated by strain-gauge plethysmography. Fourteen mild to moderate hypertensives (8 males, 6 females, age range 40-60 years) were randomly given magnesium or placebo in a double-blind parallel clinical trial for 6 months. In the actively treated group magnesium urinary excretion increased from 5.3 +/- 2 to 7.7 +/- 2 mmol/24 h, and serum magnesium changed from 0.9 +/- 0.1 to 1.0 +/- 0.2 mmol/l. On magnesium, BP changed at rest from 156/97 +/- 12/4 to 149/90 +/- 8/3 mm Hg, during cold pressor test from 169/105 +/- 9/6 to 174/105 +/- 15/4, during isometric exercise from 170/107 +/- 13/9 to 170/105 +/- 20/6, and during tilt test from 149/96 +/- 11/6 to 153/96 +/- 17/7 mm Hg. Similar changes were observed in the placebo group. Peripheral resistances were 14.7 +/- 4 and 9.8 +/- 2 PRU before and after magnesium, respectively. These data indicate that long-term magnesium pidolate supplementation does not affect blood pressure at rest and during sympathetic stimulation, despite a slight, nonsignificant reduction in forearm peripheral resistance.
本临床试验的主要目的是评估匹多酸镁（15毫摩尔/天）对静息血压以及冷刺激、等长运动和倾斜试验诱发的交感神经刺激期间血压的影响；采用应变片体积描记法评估外周血流量。在一项双盲平行临床试验中，14名轻度至中度高血压患者（8名男性，6名女性，年龄范围40 - 60岁）被随机给予镁剂或安慰剂，为期6个月。在积极治疗组中，尿镁排泄量从5.3±2增加至7.7±2毫摩尔/24小时，血清镁从0.9±0.1变为1.0±0.2毫摩尔/升。服用镁剂后，静息血压从156/97±12/4毫米汞柱变为149/90±8/3毫米汞柱，冷加压试验期间从169/105±9/6变为174/105±15/4，等长运动期间从170/107±13/9变为170/105±20/6，倾斜试验期间从149/96±11/6变为153/96±17/7毫米汞柱。安慰剂组观察到类似变化。服用镁剂前后外周阻力分别为14.7±4和9.8±2外周阻力单位。这些数据表明，长期补充匹多酸镁不会影响静息血压以及交感神经刺激期间的血压，尽管前臂外周阻力有轻微、无显著意义的降低。
