热带糖尿病中的对氨基苯甲酸/对氨基水杨酸试验

The BT-PABA/PAS test in tropical diabetes.

作者信息

Gagee P, Pemberton P, Lobley R, Chaloner C, Snehalatha C, Mohan V, Braganza J M

机构信息

Department of Medicine (Gastroenterology), Royal Infirmary, Manchester, UK.

出版信息

Clin Chim Acta. 1992 Nov 30;212(3):103-11. doi: 10.1016/0009-8981(92)90177-r.

DOI:10.1016/0009-8981(92)90177-r

PMID:1477973

Abstract

A 'screening' test is needed to identify patients with chronic pancreatitis among diabetics in tropical field surveys. We have examined the potential diagnostic yield of the BT-PABA/PAS test of exocrine pancreatic function in this setting. The recoveries of both PABA and PAS in eight healthy controls from Madras, south India, were lower than in controls from Manchester, north west England (mean +/- S.D., 51 +/- 11 vs. 79 +/- 7%, P < 0.001 for PABA; 52 +/- 11% vs. 81 +/- 7%, P < 0.001 for PAS) but the % PABA/PAS excretion index (PEI) was similar (0.96 +/- 0.14 vs. 0.96 +/- 0.06). Using a cut-off value of 0.75 for the PEI in a study group including eight patients with chronic pancreatitis and 26 with primary forms of diabetes, test sensitivity was 75%, specificity 92%, positive predictive value 75%, negative predictive value 92% and efficiency 88%.

摘要

在热带地区的现场调查中，需要一种“筛查”测试来识别糖尿病患者中的慢性胰腺炎患者。我们在此环境下研究了外分泌胰腺功能的BT-PABA/PAS测试的潜在诊断价值。来自印度南部马德拉斯的8名健康对照者中PABA和PAS的回收率低于英格兰西北部曼彻斯特的对照者（平均值±标准差，PABA为51±11%对79±7%，P<0.001；PAS为52±11%对81±7%，P<0.001），但PABA/PAS排泄指数（PEI）相似（0.96±0.14对0.96±0.06）。在一个包括8名慢性胰腺炎患者和26名原发性糖尿病患者的研究组中，使用PEI的临界值0.75，测试敏感性为75%，特异性为92%，阳性预测值为75%，阴性预测值为92%，效率为88%。