Prentice A, Randall B J, Weddell A, McGill A, Henry L, Horne C H, Thomas E J
Department of Obstetrics and Gynaecology, Newcastle General Hospital, Newcastle upon Tyne, UK.
Hum Reprod. 1992 Oct;7(9):1318-25. doi: 10.1093/oxfordjournals.humrep.a137848.
Endometriosis is an oestrogen dependent condition and it is expected that the tissue of origin of endometriosis will express receptors for the ovarian steroids. Two epithelia, endometrium and peritoneal mesothelium, are the potential parent epithelium. Oestrogen and progesterone receptor expression has been studied immunohistochemically in (i) timed endometrial biopsies from 25 normal subjects and 27 patients with endometriosis, (ii) 25 endometriotic biopsies and (iii) 42 peritoneal biopsies. Endometrium but not peritoneal mesothelium expresses both oestrogen and progesterone receptors. No difference in the intensity of staining between endometria of normal subjects compared with the endometria of patients with endometriosis was noted. In paired endometrial and endometriotic biopsies, the intensity of staining for the oestrogen receptor in stromal cells and for the progesterone receptor in both glandular and stromal cells was less in the endometriotic biopsies. These data provide circumstantial evidence for an endometrial origin for endometriosis although quantitative differences exist in receptor expression between endometrium and endometriosis.
子宫内膜异位症是一种雌激素依赖性疾病，预计子宫内膜异位症的起源组织会表达卵巢甾体激素的受体。两种上皮组织，即子宫内膜和腹膜间皮，是潜在的母上皮组织。已采用免疫组织化学方法研究了雌激素和孕激素受体的表达情况，研究对象包括：（i）来自25名正常受试者和27名子宫内膜异位症患者的定时子宫内膜活检组织；（ii）25份子宫内膜异位症活检组织；（iii）42份腹膜活检组织。子宫内膜表达雌激素和孕激素受体，而腹膜间皮不表达。未观察到正常受试者的子宫内膜与子宫内膜异位症患者的子宫内膜在染色强度上存在差异。在配对的子宫内膜和子宫内膜异位症活检组织中，子宫内膜异位症活检组织中基质细胞雌激素受体以及腺细胞和基质细胞孕激素受体的染色强度较低。这些数据为子宫内膜异位症起源于子宫内膜提供了间接证据，尽管子宫内膜和子宫内膜异位症之间在受体表达上存在定量差异。
