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J Clin Pathol. 1992 Dec;45(12):1114-5. doi: 10.1136/jcp.45.12.1114.
2
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APMIS. 1990 Sep;98(9):797-811. doi: 10.1111/j.1699-0463.1990.tb05000.x.
3
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Tumor immunolocalization using monoclonal antibodies which bind placental alkaline phosphatase.使用结合胎盘碱性磷酸酶的单克隆抗体进行肿瘤免疫定位。
Prog Clin Biol Res. 1984;166:245-56.

本文引用的文献

1
Preparation and characterization of monoclonal antibodies against placental alkaline phosphatase and other human trophoblast-associated determinants.抗胎盘碱性磷酸酶及其他人类滋养层相关决定簇单克隆抗体的制备与特性分析
Int J Cancer. 1984 May 15;33(5):633-41. doi: 10.1002/ijc.2910330514.
2
Immunocytochemical staining with monoclonal antibodies in cytologically "negative" serous effusions from patients with malignant disease.用单克隆抗体对恶性疾病患者细胞学检查“阴性”的浆液性积液进行免疫细胞化学染色。
J Clin Pathol. 1983 Oct;36(10):1150-3. doi: 10.1136/jcp.36.10.1150.
3
Enzyme-antigen immunoassay for human placental alkaline phosphatase in serum and tissue extracts, and its application as a tumor marker.血清和组织提取物中人类胎盘碱性磷酸酶的酶-抗原免疫测定及其作为肿瘤标志物的应用。
Clin Chem. 1985 Jan;31(1):41-5.
4
Increased serum placental-like alkaline phosphatase activity in smokers originates from the lungs.吸烟者血清中胎盘样碱性磷酸酶活性增加源于肺部。
Eur J Respir Dis. 1987 Sep;71(3):170-6.
5
Placental alkaline phosphatase as a tumor marker for primary intracranial germinoma.胎盘碱性磷酸酶作为原发性颅内生殖细胞瘤的肿瘤标志物。
J Neurosurg. 1988 May;68(5):710-20. doi: 10.3171/jns.1988.68.5.0710.
6
Serum placental-like alkaline phosphatase (PLAP): a novel combined enzyme linked immunoassay for monitoring ovarian cancer.血清胎盘样碱性磷酸酶（PLAP）：一种用于监测卵巢癌的新型联合酶联免疫测定法。
J Clin Pathol. 1989 Jan;42(1):40-5. doi: 10.1136/jcp.42.1.40.
7
Tumour associated antigens in diagnosis of serous effusions.肿瘤相关抗原在浆液性积液诊断中的应用
J Clin Pathol. 1988 Jun;41(6):633-43. doi: 10.1136/jcp.41.6.633.
8
Placental-like alkaline phosphatase from ovary and ascites of a patient with a malignant ovarian tumour.
Clin Chim Acta. 1990 Jan 15;186(2):295-9. doi: 10.1016/0009-8981(90)90047-v.
9
Placental-type alkaline phosphatase in peritoneal fluid of women with endometriosis.子宫内膜异位症女性腹腔液中的胎盘型碱性磷酸酶
Clin Chim Acta. 1990 Jan 15;186(2):285-94. doi: 10.1016/0009-8981(90)90046-u.

良性和恶性胸腔积液中胎盘碱性磷酸酶活性的测定。

Measurement of placental alkaline phosphatase activity in benign and malignant pleural effusions.

作者信息

Fergusson R J, Fisken J, McIntyre M A, Roulston J E, Leonard R C

机构信息

Department of Clinical Oncology, Western General Hospital, Edinburgh.

出版信息

J Clin Pathol. 1992 Dec;45(12):1114-5. doi: 10.1136/jcp.45.12.1114.

DOI:10.1136/jcp.45.12.1114
PMID:1479040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC495009/
Abstract

The usefulness of placental alkaline phosphatase (PLAP) as a diagnostic marker of malignancy was assessed in pleural fluid from 60 patients with effusions. Pleural fluid PLAP activities were measured by an enzyme linked immunoassay (ELISA) using the two monoclonal antibodies H17E2 and H317. Similar values were found in groups of patients with primary bronchial tumours (n = 12), secondary malignancies (n = 23), and "benign" conditions (n = 25). The highest values were found in a small subgroup of patients with metastatic ovarian carcinoma. However, the production of this enzyme by normal lung makes the measurement of PLAP in pleural fluid unhelpful as a diagnostic aid to distinguish "benign" from malignant effusions.

摘要

对60例胸腔积液患者的胸水进行检测，评估胎盘碱性磷酸酶（PLAP）作为恶性肿瘤诊断标志物的效用。使用两种单克隆抗体H17E2和H317，通过酶联免疫吸附测定法（ELISA）测量胸水PLAP活性。在原发性支气管肿瘤患者组（n = 12）、继发性恶性肿瘤患者组（n = 23）和“良性”疾病患者组（n = 25）中发现了相似的值。在一小部分转移性卵巢癌患者中发现了最高值。然而，正常肺组织会产生这种酶，这使得胸水PLAP的测量无助于区分“良性”和恶性胸腔积液，不能作为诊断辅助手段。