Zubieta J K, Alessi N E
Maternal and Child Health Center, University of Michigan Medical Center, Ann Arbor.
J Clin Psychopharmacol. 1992 Oct;12(5):346-51.
We report the results of an open trial of trazodone in the treatment of severe behavioral disturbances in a sample of 22 hospitalized children previously found to be unresponsive to other treatments. Response to treatment was assessed by overall clinical criteria and improvements in individual symptom dimensions during the inpatient hospitalization. Thirteen children (67%) were found to benefit from the introduction of trazodone. Aggressive, impulsive behaviors were symptoms most frequently improved by this agent. Three of those found to be nonresponders actually worsened in symptomatology. A follow-up interview of the parents was conducted 3-14 months after discharge from the inpatient unit, for those children who initially responded to trazodone administration. The results of this interview suggest that the effect of trazodone was persistent for a prolonged period of time after the initial inpatient trial. Trazodone appears to be of value in the management of severe behavioral disturbances in children. The possible mechanism of action of trazodone is discussed.
我们报告了一项曲唑酮治疗严重行为障碍的开放试验结果，该试验针对22名住院儿童样本，这些儿童此前被发现对其他治疗无反应。通过总体临床标准以及住院期间个体症状维度的改善情况来评估治疗反应。发现13名儿童（67%）从引入曲唑酮治疗中获益。攻击性行为、冲动行为是该药物最常改善的症状。发现有3名无反应者实际上症状加重。对于最初对曲唑酮给药有反应的儿童，在从住院部出院后3至14个月对其父母进行了随访访谈。此次访谈结果表明，曲唑酮的效果在最初的住院试验后持续了较长时间。曲唑酮在治疗儿童严重行为障碍方面似乎具有价值。文中还讨论了曲唑酮可能的作用机制。
