Mani G V, Shurey C, Green C J
Section of Surgical Research, Northwick Park Hospital, Harrow.
J Hand Surg Br. 1992 Oct;17(5):536-43. doi: 10.1016/s0266-7681(05)80238-4.
Revascularization and regeneration through vascularized and non-vascularized nerve grafts were compared on optimal and adverse graft beds in 76 rabbit sciatic nerves. A delay in revascularization of more than 14 days was found to occur in 30 mm long, non-vascularized nerve grafts placed on completely avascular graft graft beds. However, over a period of 44 weeks, this prolonged ischaemia did not adversely affect nerve regeneration. The vascularized nerve grafts did not differ significantly with respect to the rate of regeneration, motor conduction velocity, fibre diameter and thickness of myelin sheath. In rabbits, the provision of early vascularity does not appear to confer superior regeneration through nerve grafts. The clinical use of vascularized nerve grafts is discussed in the light of these results.
在76只兔的坐骨神经上，比较了带血管神经移植和不带血管神经移植在最佳和不利移植床上的血管重建和再生情况。发现在完全无血管的移植床上植入30毫米长的不带血管神经移植物时，血管重建延迟超过14天。然而，在44周的时间里，这种长时间的缺血对神经再生没有不利影响。带血管神经移植在再生速度、运动传导速度、纤维直径和髓鞘厚度方面没有显著差异。在兔中，早期提供血管似乎并不能通过神经移植带来更好的再生效果。根据这些结果讨论了带血管神经移植的临床应用。
