Kanaya F, Firrell J, Tsai T M, Breidenbach W C
Christine M. Kleinert Institute for Hand and Micro Surgery, University of Louisville School of Medicine, Ky.
Plast Reconstr Surg. 1992 May;89(5):924-30. doi: 10.1097/00006534-199205000-00024.
Functional results of vascularized nerve grafts (VNG), end-to-end (E-E) repair, and nonvascularized nerve grafts (NNG) were compared using 75 rats. For all three groups, the sciatic function index (SFI) was measured for 12 weeks. For the vascularized nerve graft and nonvascularized nerve graft groups, it was measured every 4 weeks to week 36. The vascularized nerve graft and end-to-end repair groups showed significantly better recovery than the nonvascularized nerve graft group 4 weeks after surgery, and this pattern continued throughout the experiment. Results from the vascularized nerve graft and end-to-end repair groups did not differ significantly. Twelve weeks after surgery, morphologic and electrophysiologic assessments were used to compare the experimental and contralateral legs. The vascularized nerve graft group showed significantly better recovery than the nonvascularized nerve graft group on all measures except muscle weight and axon count, even though the grafts were completed in a normal bed.
使用75只大鼠比较了血管化神经移植（VNG）、端端（E-E）修复和非血管化神经移植（NNG）的功能结果。对所有三组，均测量坐骨神经功能指数（SFI）达12周。对于血管化神经移植组和非血管化神经移植组，每4周测量一次，直至第36周。血管化神经移植组和端端修复组在术后4周时的恢复情况明显优于非血管化神经移植组，且这种模式在整个实验过程中持续存在。血管化神经移植组和端端修复组的结果无显著差异。术后12周，采用形态学和电生理学评估来比较实验侧腿和对侧腿。血管化神经移植组在除肌肉重量和轴突计数外的所有指标上的恢复情况均明显优于非血管化神经移植组，尽管移植是在正常床中完成的。
