Koshima I, Harii K
J Hand Surg Am. 1985 Jan;10(1):64-72. doi: 10.1016/s0363-5023(85)80249-5.
Rat sciatic nerves were used in a comparative study of both vascularized and free nerve grafts that were transplanted into an acute burn wound. Electromyographic analyses of axonal regeneration were done at intervals from week 1 through week 24 after surgery. Biopsied sciatic nerves were processed for morphometric studies with the use of a fiber caliber analyzer. Motor nerve conduction velocity was faster in the vascularized nerve graft than in the free nerve graft until week 24 after surgery. Regenerated axons appeared earlier in the vascularized nerve grafts than in the free nerve grafts, and the density of large regenerated axons was greater in the former than in the latter group. It is suggested that preserving the vascular system of vascularized nerve grafts would decrease the likelihood of fibrosis and result in smooth regeneration of axons.
在一项将血管化神经移植物和游离神经移植物移植到急性烧伤创面的比较研究中，使用了大鼠坐骨神经。术后从第1周到第24周定期进行轴突再生的肌电图分析。对活检的坐骨神经使用纤维直径分析仪进行形态计量学研究。直到术后第24周，血管化神经移植物中的运动神经传导速度比游离神经移植物中的更快。再生轴突在血管化神经移植物中比在游离神经移植物中出现得更早，并且前一组中大型再生轴突的密度大于后一组。提示保留血管化神经移植物的血管系统会降低纤维化的可能性，并导致轴突的顺利再生。
