Tsuda H, Doi H, Inada T, Shirono K
Division of Clinical Hematology and Immunology, Kumamoto City Hospital.
Rinsho Ketsueki. 1994 Jul;35(7):717-9.
A 34-year-old woman was admitted because of pancytopenia with DIC in the 28th week of pregnancy. Bone marrow aspirate demonstrated 81.2% abnormal cells which showed Auer bodies and faggot formation. Chromosomal analysis demonstrated an abnormality, t (15; 17). The patient was diagnosed as having acute promyelocytic leukemia (APL) and started to receive treatment with all-trans retinoic acid (ATRA) 70 mg/body/day per os. She had a cesarean section and gave birth to a female infant in the 29th week of pregnancy. An increase of WBC counts was observed on the 9th hospital day, then chemotherapy with anti-cancer agents was performed additionally. Complete remission was achieved on the 27th hospital day. Management of pregnant patients with APL could be improved by using ATRA instead of conventional combinations of cytotoxic agents.
一名34岁女性因妊娠28周时出现全血细胞减少伴弥散性血管内凝血（DIC）入院。骨髓穿刺显示81.2%的异常细胞，这些细胞可见奥氏小体和柴捆样形成。染色体分析显示异常，t（15；17）。该患者被诊断为急性早幼粒细胞白血病（APL），开始口服全反式维甲酸（ATRA）70mg/（日·体）进行治疗。她在妊娠29周时行剖宫产，产下一名女婴。住院第9天观察到白细胞计数增加，随后额外进行了抗癌药物化疗。住院第27天实现完全缓解。使用ATRA而非传统的细胞毒性药物联合方案可改善APL妊娠患者的治疗管理。
