Shikimi T, Hattori K, Takaori S
Department of Pharmacology, Shimane Medical University, Japan.
Jpn J Pharmacol. 1992 Oct;60(2):97-103. doi: 10.1254/jjp.60.97.
A human urinary trypsin inhibitor, urinastatin (UT)-like immunoreactive substance with trypsin inhibitory activity, was demonstrated in certain brain regions in rats, especially the cerebral cortex, hippocampus and hypothalamus. Although this UT-like substance in the rat brain displayed an N-terminal amino acid sequence similar to that of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), it did not show any GAPDH activity. These results indicate that the UT-like substance in the rat brain is a protein different from GAPDH and indicates a localized distribution within certain brain regions partly related to learning and memory.
在大鼠的某些脑区，特别是大脑皮层、海马体和下丘脑，发现了一种具有胰蛋白酶抑制活性的人尿胰蛋白酶抑制剂——尿抑素（UT）样免疫反应性物质。尽管大鼠脑中的这种UT样物质显示出与甘油醛-3-磷酸脱氢酶（GAPDH）相似的N端氨基酸序列，但它没有表现出任何GAPDH活性。这些结果表明，大鼠脑中的UT样物质是一种不同于GAPDH的蛋白质，并表明其在某些与学习和记忆部分相关的脑区内呈局部分布。
