Butler J J
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Semin Diagn Pathol. 1992 Nov;9(4):252-6.
Histologic criteria for the diagnosis of Hodgkin's disease are being modified, primarily as a result of phenotypic analysis. It seems likely that non-Hodgkin's lymphomas have been diagnosed as mixed-cellularity and lymphocytic-depletion Hodgkin's disease on the basis of previously accepted histologic criteria. As a result, phenotypic studies are indicated in all examples of lymphocytic-depletion Hodgkin's disease and in those cases of mixed-cellularity Hodgkin's disease in which the histologic findings are unusual. The effects of genotypic analysis on histologic criteria remain to be elucidated.
霍奇金病诊断的组织学标准正在修订，这主要是表型分析的结果。基于先前公认的组织学标准，非霍奇金淋巴瘤似乎被诊断为混合细胞型和淋巴细胞消减型霍奇金病。因此，对于所有淋巴细胞消减型霍奇金病病例以及那些组织学表现不寻常的混合细胞型霍奇金病病例，都需要进行表型研究。基因分析对组织学标准的影响仍有待阐明。
