Chang T H, Baum B
Department of Molecular Genetics, Ohio State University, Columbus 43210.
Yeast. 1992 Nov;8(11):973-5. doi: 10.1002/yea.320081107.
An 'electronic' gene mapping procedure based on computer-aided search for overlapping gene sequences was used to identify adjacent genes and localize several putative RNA helicase genes to different chromosomes. PRP28 and AMD1 genes map to the right arm of chromosome IV next to sup2, which encodes a tyrosine tRNA. PRP16, previously mapped to chromosome XI, is tightly linked to MRP-L20. PRP22 is adjacent to PRE1, whose chromosomal location is currently unknown. The utility of this approach in yeast gene mapping is evaluated.
一种基于计算机辅助搜索重叠基因序列的“电子”基因定位程序被用于识别相邻基因，并将几个假定的RNA解旋酶基因定位到不同的染色体上。PRP28和AMD1基因定位于第四条染色体的右臂，紧挨着编码酪氨酸tRNA的sup2。先前定位于第十一条染色体的PRP16与MRP-L20紧密连锁。PRP22与PRE1相邻，PRE1的染色体位置目前未知。评估了这种方法在酵母基因定位中的实用性。
